Hemodialysis. Z49.1
Conditions
Interventions
Intervention 1: Intervention Group: One Hundred milliliters of normal saline is flushed through the arterial line of extracorporeal tubing three times during the 4-hour period of hemodialysis (once
i.e, receiving 5000 units of unfractionated heparin during hemodialysis. The intervention is for 2 consecutive hemodialysis sessions. Intervention 2: Control Group: The group is dialyzed based on the
Treatment - Other
Intervention Group: One Hundred milliliters of normal saline is flushed through the arterial line of extracorporeal tubing three times during the 4-hour period of hemodialysis (once every hour) in
i.e, receiving 5000 units of unfractionated heparin during hemodialysis. The intervention is for 2 consecutive hemodialysis sessions.
Control Group: The group is dialyzed based on the standard protocol: Five thousands units of unfractionated heparin are given during the 4-hour period of hemodialysis but no intermittent saline flush.
Sponsors
Vice Chancellor for Research and Innovation, Golestan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Patients with end-stage renal disease treated with maintenance hemodialysis for at least six months; Age above 18 years old; Willingness to participate in the study; On 3 times per week, 4-hours long maintenance hemodialysis; Arteriovenous Fistula or Graft access type; Receives 5000 units of unfractionated heparin during each session of hemodialysis; Hemoglobin concentration 9 to 14 grams per deciliter. Exclusion Criteria: Having acute debilitating disease (cardiovascular, hypertension, cancer and acute infection); Having systolic blood pressure below 90 and above 160 mm Hg.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adequacy of Hemodialysis (KT/V) and Urea Reduction Ratio (URR). Timepoint: At first and third session of hemodialysis. After a one-week washout time, again at the first and third session of hemodialysis. Method of measurement: Pre and post dialysis serum urea and calculation of URR and KT/V using formula recommended by Ministry of Health and Medical Education. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clot formation in extracorporeal tubing. Timepoint: At the end of each hemodialysis sessions. Method of measurement: By direct observation and grading. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactEinollah Mollaei
Golestan University of Medical Sciences
Outcome results
None listed