Female infertility. Female infertility associated with anovulation
Conditions
Interventions
Intervention 1: 100 mg daily clomiphene(Ovumid
Iran Hormone, Tehran, Iran) , the third day of menstruation to 5 days. Intervention 2: 5 mg letrozole (Letrozole 2.5
SOHA Pharmaceutical Co, Tehran, Iran) daily, the third day of menstruation to 5 days. Intervention 3: 100 mg daily clomiphene(Ovumid
Iran Hormone, Tehran, Iran) , the third day of menstruation to 5 days
+
5 mg letrozole (Letrozole 2.5
SOHA Pharmaceutical Co, Tehran, Iran) daily, the third day of menstruation to 5 days.
Treatment - Drugs
100 mg daily clomiphene(Ovumid
Iran Hormone, Tehran, Iran) , the third day of menstruation to 5 days
5 mg letrozole (Letrozole 2.5
SOHA Pharmaceutical Co, Tehran, Iran) daily, the third day of menstruation to 5 days
Iran Hormone, Tehran, Iran) , the third day of menstruation to 5 days
+
5 mg letrozole (Letrozole 2.5
Sponsors
Vice Chancellor for research of Iran Univercity of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Women with history of infertility more over than one year and diagnosis of PCOS based on the revised 2003 . Exclusion criteria: Women older than 40 years or younger than 20; fallopian tubes abnormality proved by hysterosalpingography; abnormal semen analysis for their partners according to the modified criteria of the World Health Organization; endocrine problem like hyper or hypo thyroidism, hyperprolactinemia; abnormal karyotype.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ovulation. Timepoint: Day 11 of the Menstrual cycle. Method of measurement: Transvaginal sonography.;Pregnancy. Timepoint: After retard of mense. Method of measurement: Pregnancy test by missuring B-hCG.;The number of follicles. Timepoint: Day 11 of the menstrual cycle. Method of measurement: Transvaginal sonography.;Follicle size. Timepoint: Day 11 of the menstrual cycle. Method of measurement: Transvaginal sonography.;Endometrial thickness. Timepoint: Day 11 of menstural sicle. Method of measurement: Trans aginal sonography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Multiple pregnancies. Timepoint: 4-6 weeks after menstural delay. Method of measurement: Pregnancy sonography.;Abortions under 20 weeks. Timepoint: After pegnancy. Method of measurement: Pregnancy sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Sara Ghareh Sheikhlou
Iran University of Medical Sciences
Outcome results
None listed