Turmeric effect on treatment non-alcoholic fatty liver disease

The effect of Turmeric on lipid profile, malondialdehyde, liver echogenicity and enzymes in patients with non-alcoholic fatty liver

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015092924262N1

Enrollment

Registered

2015-10-25

Start date

2015-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non alcoholic fatty liver disease. Fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: Cap containing placebo, 2 gr flour for daily usage for 2 month. Intervention 2: Turmeric with daily dose 2 gr for 2 month.

Placebo

Treatment - Drugs

Cap containing placebo, 2 gr flour for daily usage for 2 month

Turmeric with daily dose 2 gr for 2 month

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: diagnosed fatty liver disease; absence of pregnancy and lactation; absence of diabetes, liver and biliary disorders, Celiac disease and cirrhosis, hepatitis B, C and autoimmune hepatitis. Lack of high blood pressure, cardiovascular disease, lung disease, kidney disease, cancer, thyroid, Wilson and hereditary hematochromatosis, no history of hospitalization or athlete, non-surgical weight loss in the last year, taking drugs like tamoxifen, lithium, phenytoin, antibiotics, metformin, Ursodeoxycholic acid (UDCA), no alcohol, no smoking, no history of hypothyroidism and Cushing's syndrome

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Aspartate aminotransferase. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration of AST with enzymatic method with kit.;Alanine aminotransferase. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration of ALT in blood with enzymatic method with kit.;Gamma-glutamyl transpeptidase. Timepoint: Before intervention, 2 month later of intervention. Method of measurement: Concentration of GGT in blood with enzymatic method with kit.;Fasting blood sugar. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration Fasting blood sugar with enzymatic method with kit.;Total cholestrol. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration cholestrol of serum in fasting stage with enzymatic method with kit.;HDL-C. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration of HDL-C serum in fasting stage with enzymatic method with kit.;LDL-C. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration of LDL-C serum in fasting stage with fried method.;VLDL. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration of VLDL serum in fasting stage with TG/5 Method.;Triglyciride. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration of TG serum in fasting stage with enzymatic method with kit.;Hepatic steatosis. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Using ultrasound.;MDA. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration of MDA serum in fasting stage with enzymatic method with kit.	—

Measure

Time frame

Aspartate aminotransferase. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration of AST with enzymatic method with kit.;Alanine aminotransferase. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration of ALT in blood with enzymatic method with kit.;Gamma-glutamyl transpeptidase. Timepoint: Before intervention, 2 month later of intervention. Method of measurement: Concentration of GGT in blood with enzymatic method with kit.;Fasting blood sugar. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration Fasting blood sugar with enzymatic method with kit.;Total cholestrol. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration cholestrol of serum in fasting stage with enzymatic method with kit.;HDL-C. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration of HDL-C serum in fasting stage with enzymatic method with kit.;LDL-C. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration of LDL-C serum in fasting stage with fried method.;VLDL. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration of VLDL serum in fasting stage with TG/5 Method.;Triglyciride. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration of TG serum in fasting stage with enzymatic method with kit.;Hepatic steatosis. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Using ultrasound.;MDA. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Concentration of MDA serum in fasting stage with enzymatic method with kit.

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Secondary

Measure	Time frame
Weight. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Weight with Kilograms unit.;Body mass index. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Weight in Kilograms over Height in meters squared.;Total protein intake. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Dietary recall questionnaire.;Waist circumference. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Upper hip bone and place a measuring tape around the abdomen.;Hip circumference. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Hight waist circumference with measuring tape.;Blood pressure. Timepoint: Before intervention, 2 months after intervention. Method of measurement: (SBP-DBP)+ (DPB)/3.;AST/ALT Ratio. Timepoint: Before intervention, 2 months after intervention. Method of measurement: From divition of AST on ALT was made.;WHR. Timepoint: Before intervention, 2 months after intervention. Method of measurement: waist circumference to Hip circumference ratio.;Total energy intake. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Dietary recall questionnaire.;Total carbohydrate intake. Timepoint: Before intervention, 2 month later of intervention. Method of measurement: Dietary recall questionnaire.;Total fat intake. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Dietary recall questionnaire.	—

Measure

Time frame

Weight. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Weight with Kilograms unit.;Body mass index. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Weight in Kilograms over Height in meters squared.;Total protein intake. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Dietary recall questionnaire.;Waist circumference. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Upper hip bone and place a measuring tape around the abdomen.;Hip circumference. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Hight waist circumference with measuring tape.;Blood pressure. Timepoint: Before intervention, 2 months after intervention. Method of measurement: (SBP-DBP)+ (DPB)/3.;AST/ALT Ratio. Timepoint: Before intervention, 2 months after intervention. Method of measurement: From divition of AST on ALT was made.;WHR. Timepoint: Before intervention, 2 months after intervention. Method of measurement: waist circumference to Hip circumference ratio.;Total energy intake. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Dietary recall questionnaire.;Total carbohydrate intake. Timepoint: Before intervention, 2 month later of intervention. Method of measurement: Dietary recall questionnaire.;Total fat intake. Timepoint: Before intervention, 2 months after intervention. Method of measurement: Dietary recall questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Jarahzadeh

Ahvaz Jundishapur University of Medical Sciences

maryam.jarhzadeh@gmail.com; jarahzadeh.m@ajums.ac.ir+98 21 7755 9737

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026