Soft tissue sarcoma of the extremities. Malignant neoplasm of other connective and soft tissue
Conditions
Interventions
Intervention 1: Intervention group: 3DCRT 46-50Gy/23-25 fr plus Concurrent Chemotherapy with Epirubicin and Ifosfamide and then Surgical Resection. Intervention 2: Control group: 3DCRT 46-50Gy/23-25 f
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Pathological diagnosis of soft tissue sarcoma in extremity Tumor size over 5 cm based on CT scan or MRI
Exclusion criteria
Exclusion criteria: Not tolerating chemotherapy due to underlying renal, hepatic or cardiac problems or insufficient bone marrow reserve Recurrent o metastatic tumors Pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment-induced toxicities. Timepoint: Weekly during intervention, 4, 12 and 24 weeks after intervention. Method of measurement: Interviewing patient and physical examination including inspection and palpation, lab data and imaging.;Pathological response. Timepoint: After surgery. Method of measurement: Inspection of surgical specimen by the pathologist and defining the extent of tumor tissue necrosis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Post-op complications. Timepoint: 4 weeks after surgery. Method of measurement: Interviewing and examining the patient.;Local recurrence. Timepoint: 6,12 and 24 month after surgery. Method of measurement: Physical exam and imaging.;Distant metastasis. Timepoint: 6,12 and 24 month after surgery. Method of measurement: Physical exam and imaging. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactReza Ghalehtaki
Tehran University of Medical Sciences
Outcome results
None listed