brain injury. Concussion,Traumatic cerebral oedema, Diffuse brain injury, Focal brain injury, Epidural haemorrhage,Traumatic subdural haemorrhage,Traumatic subarachnoid haemorrhage, Intracranial injury with prolonged coma, Other intracranial injuries, Intracranial inju
Conditions
Interventions
Intervention 1: One groups receives at a dose of 20ml / h and furosemide for 0.05mg / kg / h for 72 hours . Intervention 2: Control group receives for 72 hours at a dose of 20ml /h saline hyperton.
Treatment - Drugs
One groups receives at a dose of 20ml / h and furosemide for 0.05mg / kg / h for 72 hours .
Control group receives for 72 hours at a dose of 20ml /h saline hyperton
Sponsors
Mazandaran University of Medical Sciences, Vice chancellor for research
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: All of patients with 18-90 years old with closed head trauma ; associated with brain edema confirmed with CT scan ; Hemodynamically stable before management; GCS<14; Patients with CV line ; admission with in 24 hours of initial insult
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bloood Na. Timepoint: 1,2.3.4 days. Method of measurement: Serum concentraion.;Blood osmolality. Timepoint: 1,2,3,4 days. Method of measurement: With calculation of ions affect the osmolarity. | — |
Secondary
| Measure | Time frame |
|---|---|
| ??S100B. Timepoint: 1,2,3,4 days. Method of measurement: Kit (spectrophotometery).;NSE. Timepoint: 1,3,5. Method of measurement: Kit (spectrophotometery). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Marziyeh Jafari
Mazandaran University of Medical Sciences
Outcome results
None listed