Effect of Tranexamic Acid On intraoperative Bleeding

Evaluating the effect of intravenous tranexamic acid on intraoperative bleeding during elective rhinoplasty surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015092824241N1

Enrollment

Registered

2015-11-07

Start date

2014-10-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraoperative Bleeding during Rhinoplasty.

Interventions

Intervention 1: Intervention Group 1: Study subjects in the treatment arm will be administered with a bolus intravenous dose of tranexamic acid (10 milligram per kilogram, Caspian – Tamin Pharmaceuti

Prevention

Placebo

Intervention Group 1: Study subjects in the treatment arm will be administered with a bolus intravenous dose of tranexamic acid (10 milligram per kilogram, Caspian – Tamin Pharmaceutical Company, Ras

Control Group: Subjects in the control group will receive normal saline as the placebo. Anesthesia is attempted similarly for all patients. Briefly, propofol 2 milligram per kg and fentanyl 1 micro-gr

Eligibility

Sex/Gender

All

Age

16 Years to 42 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Normotensive patients scheduled for elective open rhinoplasty aged 16-42 years without a history of bleeding diathesis with ASA (American Society of Anesthesiologists) class of either I or II. Exclusion Criterai: patients with uncontrolled hypertension; history of hypersensitivity to tranexamic acid; brain vascular diseases; coronary artery diseases; cardiac dysrhythmia; liver/kidney or metabolic disorders; patients with ASA class of either III or IV.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Estimated amount of intraoperative bleeding. Timepoint: During surgery (starting from the incision till wound closure). Method of measurement: The volume of blood suctioned during a surgery is calculated by subtracting the amount of irrigation fluid used during a surgery from the total amount of fluid gathered in suction canister at the end of surgery. The volume of blood absorbed by 4*4 inch gauzes during an operation is calculated by multiplying the number of gauzes completely soaked with blood by 10 milliliters (an estimated average of blood absorbed per gauze). These two values are then added to estimate the total intraoperative volume of blood loss.	—

Measure

Time frame

Estimated amount of intraoperative bleeding. Timepoint: During surgery (starting from the incision till wound closure). Method of measurement: The volume of blood suctioned during a surgery is calculated by subtracting the amount of irrigation fluid used during a surgery from the total amount of fluid gathered in suction canister at the end of surgery. The volume of blood absorbed by 4*4 inch gauzes during an operation is calculated by multiplying the number of gauzes completely soaked with blood by 10 milliliters (an estimated average of blood absorbed per gauze). These two values are then added to estimate the total intraoperative volume of blood loss.

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Secondary

Measure	Time frame
-. Timepoint: -. Method of measurement: -.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Ghazipoor

Ahvaz Jundishapur University of Medical Sciences

Dr.aghp@yahoo.com+98 61133809012

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026