Mitomycin effect in the treatment of urethral stenosis

The effect of locally injected Mitomycin-C after internal urethrotomy in treating urethral stricture.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015092724225N1

Enrollment

Registered

2017-04-08

Start date

2015-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

urthral stenosis. Urethral Stricture

Interventions

Intervention 1: In intervention group, internal urethrotomy is done for patients with urethral stricture

then 0.1mg/2cc mitomycin-c is injected submucosally with needle 22-gauge in incision sites

and after that urethral catheter is inserted for one week. Intervention 2: In control group, internal urethrotomy is done for patients with urethral stricture

and then urethral catheter is inserted for one week.

Treatment - Drugs

Treatment - Surgery

In intervention group, internal urethrotomy is done for patients with urethral stricture

and after that urethral catheter is inserted for one week.

In control group, internal urethrotomy is done for patients with urethral stricture

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Inclusion criteria: stenosis length <1.5 cm Exclusion criteria: Long stricture, shortness of penile, such as BXO and BPH

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Improving Urine voiding. Timepoint: Immediately after the intervention, and six months after intervention. Method of measurement: Uroflowmetry- RUG-VCUG - Cystoscopy.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Saman Najafi

Infertility and Reproductive Health Research Center

saman.najafi@gmail.com+98 21 2249 6597

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026