Effect of acid-base balance on cytokines serum level and outcome of renal transplant

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015092712203N4

Enrollment

Registered

2016-06-02

Start date

2016-05-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Failure. Renal Failure

Interventions

Intervention 1: Control Group : same volume of Intervention Group received saline. Intervention 2: Intervention Group :sodium bicarbonate base on Arterial Blood Gas Test.

Treatment - Drugs

Control Group : same volume of Intervention Group received saline

Intervention Group :sodium bicarbonate base on Arterial Blood Gas Test.

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria : Patient with End Stage Renal Disease who candidate for renal transplantation form live donor; Patient aged between 18-70 year; Patient satisfied to cooperate in this proposal. Exclusion criteria : Patient with sever heart disease; Metabolic Acidosis with PH 3 hours ;Body temperature Axillary 38.5 degree centigrade; requirement for transfusion ; age>70 year or <18 year ; Renal transplantation form cadaver; Unsatisfactory of patient ; History of tumor or immunology Disease ; Received immunomedullatory drug.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum level of IFN-y. Timepoint: Befor induction of anesthesia and aftre end of surgery. Method of measurement: Elisa Test.;Serum level of IL-2. Timepoint: Befor induction of anesthesia and aftre end of surgery. Method of measurement: Elisa Test.;Serum level of IL10. Timepoint: Befor induction of anesthesia and aftre end of surgery. Method of measurement: Elisa Test.	—

Secondary

Measure	Time frame
Cratinine. Timepoint: After surgery for one week. Method of measurement: Serum Level base on labratory base.;Urine output 24 hours. Timepoint: After surgery for one week. Method of measurement: Base of urine weight.;BUN. Timepoint: After surgery for one week. Method of measurement: Serum Level base on labratory base.;Urine output 24 hours. Timepoint: After surgery for one week. Method of measurement: Base of urine weight.	—

Measure

Time frame

Cratinine. Timepoint: After surgery for one week. Method of measurement: Serum Level base on labratory base.;Urine output 24 hours. Timepoint: After surgery for one week. Method of measurement: Base of urine weight.;BUN. Timepoint: After surgery for one week. Method of measurement: Serum Level base on labratory base.;Urine output 24 hours. Timepoint: After surgery for one week. Method of measurement: Base of urine weight.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNilofar Massoudi

Shahid Beheshti University of Medical Sciences

nilofarma@yahoo.com ; Fsafari@sbum.ac.ir; Alidabbagh@qums.ac.ir+98 22432575

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026