Schizophrenia. schizophrenia
Conditions
Interventions
Intervention 1: twenty-four patients receive pregabalin capsule75 mg/ daily up to 3weeks , then twice a day for 3 weeks next. Intervention 2: 24 patients receive Placebo capsule daily up to 3weeks
Treatment - Drugs
twenty-four patients receive pregabalin capsule75 mg/ daily up to 3weeks , then twice a day for 3 weeks next
24 patients receive Placebo capsule daily up to 3weeks then twice a day for next 3weeks
Sponsors
Vice chancellor for research, Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Diagnosis of schizophrenia according to DSM-V criteria by psychiatrist 2. Age 18 to 65 years 3. Informed consent / guardian for inclusion 4. Treatment with antipsychotics 5. Refractory schizophrenia Exclusion criteria: 1. Other psychiatric disorders axis I or II exist 2. Serious or chronic diseases like renal and liver dysfunction, severe diarrhea, cardiovascular disease, urinary tract infection, head injury 3. Pregnancy 4. Breastfeeding 5. Lack of appropriate contraception in women of reproductive age 6. Substance abuse over the past month 7. Intolerable side effects 8. History of allergy to Pregabalin 9. Change the doses of antipsychotic agents during last two weeks 10. Patient/ guardian’s apply to withdraw from the study
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and negative symptom of schizophrenia. Timepoint: Before intervention, three weeks after beginning intervention, the end of intervention. Method of measurement: Positive_and_Negative_Syndrome_Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Extra pyramidal syndrome. Timepoint: Before intervention, three weeks after beginning intervention, the end of intervention. Method of measurement: Abnormal-Involuntary-Movement-Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElham mahtiyan
Medical science of mazandaran university
Outcome results
None listed