Efficacy of traditional Persian remedy of Melissa officinalis, Rosa damascena and Pimpinella anisum in patients with irritable bowel syndrome constipation-predominant (IBS-C).

Efficacy of traditional Persian remedy of Melissa officinalis, Rosa damascena and Pimpinella anisum on clinical symptoms of patients with irritable bowel syndrome constipation-predominant (IBS-C).

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150927024228N4

Enrollment

Registered

2021-06-14

Start date

2021-10-07

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irritable Bowel Syndrome. Irritable bowel syndrome without diarrhea

Interventions

Intervention 1: Aqueous extract of capsules of Melissa officinalis, and Pimpinella anisum

and Rosa damascene powder manufactured in the School of Pharmacy of Kerman University of Medical Sciences, two times a day, each time one 500 mg capsule, half an hour before each meal, with one glass

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 18-60 years old patients with constipation-predominant irritable bowel syndrome according to Rome IV criteria.

Exclusion criteria

Exclusion criteria: Pregnancy, and breastfeeding Hypothyroidism Severe complications related to this study use of other effective drugs on irritable bowel syndrome (symptoms, quality of life, anxiety, and depression)

Design outcomes

Primary

Measure	Time frame
IBS symptom severity score. Timepoint: At the beginning of the intervention, after 4 weeks. Method of measurement: IBS symptom severity score questionnaire.;Quality of life of IBS patients. Timepoint: At the beginning of the intervention, after 4 weeks. Method of measurement: Quality of life questionnaire of IBS patients.;Anxiety and depression. Timepoint: At the beginning of the intervention, after 4 weeks. Method of measurement: Anxiety and depression questionnaire.	—

Measure

Time frame

IBS symptom severity score. Timepoint: At the beginning of the intervention, after 4 weeks. Method of measurement: IBS symptom severity score questionnaire.;Quality of life of IBS patients. Timepoint: At the beginning of the intervention, after 4 weeks. Method of measurement: Quality of life questionnaire of IBS patients.;Anxiety and depression. Timepoint: At the beginning of the intervention, after 4 weeks. Method of measurement: Anxiety and depression questionnaire.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzimi Maryam

Kerman University of Medical Sciences

dr.azimm@gmail.com+98 34 3132 8000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026