Evaluation Of the effect of cumin`s seed essential oil on Obese children by assessing biochemical biomarkers as well as evaluation of body mass index.

Evaluation of the effect of cumin`s seed essential oil on body mass index, appetite situation, insulin resistance,leptin, as well as serum concentration of TNF alpha and Zinc alpha 2 glycoprotein in 7-12 year-old obese and overweight children

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015092624198N1

Enrollment

Registered

2017-06-07

Start date

2017-05-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obesity. Obesity due to excess calories

Interventions

Intervention 1: cumin`s seed essential oil orally administered as soft gel capsules twice daily (before lunch and before dinner) 2 months duration. Intervention 2: placebo similar to the cumin seed

Treatment - Drugs

Placebo

cumin`s seed essential oil orally administered as soft gel capsules twice daily (before lunch and before dinner) 2 months duration

placebo similar to the cumin seed oil capsule in shape and color orally administered twice daily before lunch and dinner two months duration

Eligibility

Sex/Gender

All

Age

7 Years to 12 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria 1- healthy children without any history of liver disease, 2- No sign and symptoms of hypothyroidism, Cushing syndrome , diabetes 3- No sign of hypertension Exclusion criteria 1-children who show higher level of hepatic enzymes in the first laboratory evaluation.(before starting intervention) 2-children who consume glucose regulator medicine such as Glucophage or metformin. 3-children who intake any medicine which may have any interference on appetite or obesity trend such as Hydrocortisone.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
BMI. Timepoint: before intervention, two months after intervention. Method of measurement: weight in kg / height in meters squared.;Fasting blood sugar. Timepoint: before intervention, two months after intervention. Method of measurement: glucose oxidase colorimetry.;SGOT. Timepoint: before intervention,one month after intervention, two months after intervention. Method of measurement: colorimetry.;SGPT. Timepoint: before intervention,one month after intervention, two months after intervention. Method of measurement: colorimetry.;Insulin. Timepoint: before intervention, two months after intervention. Method of measurement: ELISA.;TNF alpha. Timepoint: before intervention, two months after intervention. Method of measurement: ELISA.;Zinc Alpha 2 Glycoprotein. Timepoint: before intervention, two months after intervention. Method of measurement: ELISA.;HOMA-IR. Timepoint: before intervention, two months after intervention. Method of measurement: calculation.;Leptin. Timepoint: before intervention, two months after intervention. Method of measurement: ELISA.;Total Cholestrol. Timepoint: before intervention, two months after intervention. Method of measurement: colorimetry.;TG. Timepoint: before intervention, two months after intervention. Method of measurement: calorimetri.;LDL. Timepoint: before intervention, two months after intervention. Method of measurement: colorimetry.;HDL. Timepoint: before intervention, two months after intervention. Method of measurement: colorimetry.;Appetite. Timepoint: before intervention,one month after intervention, two months after intervention. Method of measurement: CEBQ questionnaire.	—

Measure

Time frame

BMI. Timepoint: before intervention, two months after intervention. Method of measurement: weight in kg / height in meters squared.;Fasting blood sugar. Timepoint: before intervention, two months after intervention. Method of measurement: glucose oxidase colorimetry.;SGOT. Timepoint: before intervention,one month after intervention, two months after intervention. Method of measurement: colorimetry.;SGPT. Timepoint: before intervention,one month after intervention, two months after intervention. Method of measurement: colorimetry.;Insulin. Timepoint: before intervention, two months after intervention. Method of measurement: ELISA.;TNF alpha. Timepoint: before intervention, two months after intervention. Method of measurement: ELISA.;Zinc Alpha 2 Glycoprotein. Timepoint: before intervention, two months after intervention. Method of measurement: ELISA.;HOMA-IR. Timepoint: before intervention, two months after intervention. Method of measurement: calculation.;Leptin. Timepoint: before intervention, two months after intervention. Method of measurement: ELISA.;Total Cholestrol. Timepoint: before intervention, two months after intervention. Method of measurement: colorimetry.;TG. Timepoint: before intervention, two months after intervention. Method of measurement: calorimetri.;LDL. Timepoint: before intervention, two months after intervention. Method of measurement: colorimetry.;HDL. Timepoint: before intervention, two months after intervention. Method of measurement: colorimetry.;Appetite. Timepoint: before intervention,one month after intervention, two months after intervention. Method of measurement: CEBQ questionnaire.

—

Secondary

Measure	Time frame
Creatinin. Timepoint: before intervention and 2 months after intervention. Method of measurement: colorimetry.;Complete blood count. Timepoint: before intervention and 2 months after intervention. Method of measurement: microscopy.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Zyadloo

Obesity Prevention and Treatment Research Center, Shahid Beheshti University of Medical Sciences

healthydiet_28@yahoo.com+98 912 471 5191

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026