Comparison of vasovasostomy outcomes with and without local intraoperative mitomycin

Randomised clinical trial for assessment of effects of local intraoperative mitomycin during vasovasostomy on sperm analysis results

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015092324166N1

Enrollment

Registered

2016-12-12

Start date

2016-01-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male Infertility. Male infertility Incl.: Azoospermia NOS Oligospermia NOS

Interventions

Intervention 1: Inntervention group: vasovasostomy with local intraoperative mitomycin 0.2 mg/dl for 5 minutes. Intervention 2: Control group: standard vasovasostomy without local intraoperative mitom

Treatment - Surgery

Inntervention group: vasovasostomy with local intraoperative mitomycin 0.2 mg/dl for 5 minutes

Control group: standard vasovasostomy without local intraoperative mitomycin and without placebo

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Inclusion criteria: Males who undergo vasectomy. Exclusion criteria: History of urethral or bladder neck surgery; History of previous vasovasostomy; History of scrotal region radiotherapy or chemotherapy; Age of partner out of fertility range.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Presence of sperm in semen. Timepoint: Six months after surgical procedure. Method of measurement: Semen analysis.;Sperm count. Timepoint: Six months after surgical procedure. Method of measurement: Semen analysis.;Sperm motility rate. Timepoint: Six months after surgical procedure. Method of measurement: Semen analysis.;Normal morphology rate in sperms. Timepoint: Six months after surgical procedure. Method of measurement: Semen analysis.	—

Measure

Time frame

Presence of sperm in semen. Timepoint: Six months after surgical procedure. Method of measurement: Semen analysis.;Sperm count. Timepoint: Six months after surgical procedure. Method of measurement: Semen analysis.;Sperm motility rate. Timepoint: Six months after surgical procedure. Method of measurement: Semen analysis.;Normal morphology rate in sperms. Timepoint: Six months after surgical procedure. Method of measurement: Semen analysis.

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Secondary

Measure	Time frame
Hematoma in operation site. Timepoint: 1 month after procedure, 3 months after procedure and 6 months after procedure. Method of measurement: Physical examination.;Inflammatory reaction in surgical site. Timepoint: 1 month after procedure, 3 months after procedure and 6 months after procedure. Method of measurement: Physical examination.;Tissue necrosis in surgical site. Timepoint: 1 month after procedure, 3 months after procedure and 6 months after procedure. Method of measurement: Physical examination.;Failure of operation. Timepoint: 1 month after procedure, 3 months after procedure and 6 months after procedure. Method of measurement: Sperm analysis.	—

Measure

Time frame

Hematoma in operation site. Timepoint: 1 month after procedure, 3 months after procedure and 6 months after procedure. Method of measurement: Physical examination.;Inflammatory reaction in surgical site. Timepoint: 1 month after procedure, 3 months after procedure and 6 months after procedure. Method of measurement: Physical examination.;Tissue necrosis in surgical site. Timepoint: 1 month after procedure, 3 months after procedure and 6 months after procedure. Method of measurement: Physical examination.;Failure of operation. Timepoint: 1 month after procedure, 3 months after procedure and 6 months after procedure. Method of measurement: Sperm analysis.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Hamidreza Qashqai

Shahid Beheshti University of Medical Sciences, Urology department

qashqaee@sbmu.ac.ir; qashqaee@gmail.com+98 912 230 7789

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 20, 2026