Condition 1: Pneumonia. Condition 2: Pneumonia. Condition 3: Pneumonia. Pneumonia due to Klebsiella pneumoniae Pneumonia due to Pseudomonas Pneumonia due to other aerobic Gram-negative bacteria
Conditions
Interventions
Intervention 1: Colistin 9MIU loading dose as iv infusion over 1 hour then 4.5MIU every 12 hour as iv infusion over 1 hour+Meropenem 2g every 8 hour as iv infusion over 3 hours for 14 days. Interventi
Treatment - Drugs
Colistin 9MIU loading dose as iv infusion over 1 hour then 4.5MIU every 12 hour as iv infusion over 1 hour+Meropenem 2g every 8 hour as iv infusion over 3 hours for 14 days
Ampicillin-Sulbactam 3g every 4 hour as iv infusion over 1 hour and Meropenem 2g every 8 hour as iv infusion over 3 hours for 14 days
Sponsors
Vice Chancellor for Research, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Adult patients (18-65 years old) with ventilator-associated pneumonia due to multidrug resistant gram negative organisms will be included. Exclusion criteria: Infection with gram negative organism with meropenem MIC > 8 µg/ml; Infection with gram negative organism with colistin MIC > 2 µg/ml; Patients with an allergy to each of two antibiotic regimens
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical response of pneumonia to treatment regimen. Timepoint: At day 2, day 7, day 17. Method of measurement: Evaluation of fever, blood cells, pulmonary secretions, oxygenation status.;Microbiological response to treatment regimen. Timepoint: At day 2, day 7. Method of measurement: Tracheal secretion culture.;Clinical outcome of patients. Timepoint: day 7, day 14, day 21, day 28. Method of measurement: 28 days patients' follow-up.;Duration of ICU stay. Timepoint: day 7, day 14, day 21, day 28. Method of measurement: 28 days patients' follow-up. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed