The effect of adding sertraline to dapoxetine in relieving sexual problems in men

Comparative study on the efficacy of add-on sertraline or dapoxetine to PDE-5 inhibitors (phosphodiesterase type 5) on the erectile function and intra-vaginal ejaculation latency time (IELT) among patients with concomitant erectile dysfunction and premature ejaculation

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150913024006N5

Enrollment

Registered

2021-03-02

Start date

2021-04-03

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Erectile dysfunction. Male erectile dysfunction

Interventions

Intervention 1: Intervention group 1: This group of patients take a 60 mg oral tablet of dapoxetine made by Exir Pharmaceutical Company one to three hours before the start of sexual activity with the

Eligibility

Sex/Gender

Male

Age

18 Months to 80 Months

Inclusion criteria

Inclusion criteria: Erectile dysfunction anda score above 20 in the International index of Erectile Function Treatment with phosphodiesterase 5 inhibitors (such as Sildenafil, Tadalafil) more than three months before the start of the study Living in a stable and heterosexual relationship and intention for maintaining the relationship until the end of the study period Possibility of sexual intercourse at least once a week

Exclusion criteria

Exclusion criteria: ?Sensitivity to Selective Serotonin Reuptake Inhibitors(SSRI) drugs Urinary tract infections Neurological disorders History of pelvic surgery Underlying diseases such as diabetes, heart disease, hypertension, thyroid disorder Use of psychiatric drugs Alcohol consumption

Design outcomes

Primary

Measure	Time frame
Erectile function. Timepoint: Before the intervention and 4, 8, 12 weeks after the start of the intervention. Method of measurement: Erectile Performance Index Questionnaire.;Premature ejaculation. Timepoint: Before the intervention and 4, 8, 12 weeks after the start of the intervention. Method of measurement: The interval between the beginning of sexual intercourse and the time of ejaculation in minutes in the before the intervention and 4, 8, 12 weeks after the start of the intervention.	—

Measure

Time frame

Erectile function. Timepoint: Before the intervention and 4, 8, 12 weeks after the start of the intervention. Method of measurement: Erectile Performance Index Questionnaire.;Premature ejaculation. Timepoint: Before the intervention and 4, 8, 12 weeks after the start of the intervention. Method of measurement: The interval between the beginning of sexual intercourse and the time of ejaculation in minutes in the before the intervention and 4, 8, 12 weeks after the start of the intervention.

—

Secondary

Measure	Time frame
Premature ejaculation. Timepoint: Before the intervention and 4, 8, 12 weeks after the start of the intervention. Method of measurement: The interval between the beginning of sexual intercourse and the time of ejaculation in minutes.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNiloufar kiani

Esfahan University of Medical Sciences

kiani1357@gmail.com+98 31 3669 2174

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026