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Comparing crocin and misoprostol effects on cervical ripening

Comparing effects of crocin and misoprostrol consumption on cervical ripening in women undergoing operative hysteroscopy: a randomised clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20150909023949N9
Enrollment
50
Registered
2018-11-24
Start date
2019-01-05
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Uterine polyp. Condition 2: endometrial hyperplasia. Condition 3: submucosal fibroid. Condition 4: Abnormal uterine bleeding. Condition 5: excessive bleeding in the premenopausal period. Polyp of corpus uteri Endometrial glandular hyperplasia Submucous leiomyoma of uterus

Interventions

Intervention 1: Intervention group: Two crocin 15 mg tablets (Sami Saz Co. mashhad) are given to patients at 6 pm and 12 midnight before surgery. Intervention 2: Control group: Two misoprostol 100 mic

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: All women who are scheduled for operative hysteroscopy No history of allergy to saffron or prostaglandins Having written informed consent

Exclusion criteria

Exclusion criteria: Suffering from active hepatic, renal, hematologic or cardiologic disorder Approved known malignancy of genital tract Approved cervical insufficiency

Design outcomes

Primary

MeasureTime frame
Size of the largest dilator passed from cervical canal without resistance. Timepoint: After the induction of the anesthesia and before entering the hysteroscope in the operating room. Method of measurement: examination performed by the surgeon- Using standard dilators in the operating room.

Secondary

MeasureTime frame
The extent of cervical tissue softening. Timepoint: After induction of anesthesia and before entering the hysteroscope in the operating room. Method of measurement: examination by the surgeon in the operating room.;The length of time of the procedure till entering the uterine cavity. Timepoint: After induction of anesthesia in the operating room. Method of measurement: Using chronometer by the surgeon's assistant.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMansoureh Vahdat

Iran University of Medical Sciences

vahdat.m@iums.ac.ir+98 21 6435 2562

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026