Comparison of the effect of sodium valproate, levetiracetam, and lamotrigine on seizure attacks and EEG disorders in patients with juvenile myoclonic epilepsy

Comparison of the effect of sodium valproate, levetiracetam, and lamotrigine on seizure attacks and EEG disorders in patients with juvenile myoclonic epilepsy: a double blind randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201509079014N79

Enrollment

105

Registered

2015-09-18

Start date

2014-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

juvenile myoclonic epilepsy. Generalized idiopathic epilepsy and epileptic syndromes

Interventions

Intervention 1: oral levetiracetam 500 mg twice a day for 6 months. Intervention 2: oral lamotrigine 100 mg twice a day for 6 months. Intervention 3: oral sodium valproate 500 mg once a day for 6 mont

Treatment - Drugs

oral levetiracetam 500 mg twice a day for 6 months

oral lamotrigine 100 mg twice a day for 6 months.

oral sodium valproate 500 mg once a day for 6 months

Eligibility

Sex/Gender

All

Age

12 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: affected with juvenile myoclonic epilepsy; age of over 12 years. Exclusion criteria: having severe organic diseases, heart failure, liver disorder, renal disease, or electrolyte disorder; abnormal MRI image; mental retardation; pregnancy or breastfeeding; alcohol or drug dependence; needing to more than one drug for controlling seizure; noncompliance.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Assessing seizure attacks. Timepoint: before intervention, and 1, 2, and 6 months after intervention. Method of measurement: through history taking.	—

Secondary

Measure	Time frame
Assessing EEG disorders. Timepoint: before intervention, and 1, 2, and 6 months after intervention. Method of measurement: using electroencephalogram.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Sahar Moradi

Hamadan University of Medical Sciences

sahar.moradi33@yahoo.com+98 81 3388 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026