Comparison of pre- and post cardiopulmonary bypass tranexamic acid effect on the amount of bleeding after coronary artery bypass graft surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015090723933N1

Enrollment

Registered

2015-09-18

Start date

2015-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amount of bleeding in Coronary Artery Bypass Graft Surgery. Other acute ischaemic heart diseases

Interventions

Intervention 1: Intervention: 20mg/kg Tranexamic acid before surgical incision. Intervention 2: Control: 20mg/kg Tranexamic acid 10 minutes after getting Cardiopulmunary bypass.

Prevention

Intervention: 20mg/kg Tranexamic acid before surgical incision

Control: 20mg/kg Tranexamic acid 10 minutes after getting Cardiopulmunary bypass

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: Patients under 75 years old candidate for cardiopulmunary Artery Bypass Graft surgery in the operation room of Tabriz Shahid Madani Hospital. Exclusion criterua: Emergency surgery; Coagulopathy problems like Hemophilia, platelate below 100000 per ml, PT and PTT 1.5 times above normal range; Renal failure (Serum creatinine over 2mg/dl ); Allergy to Tranexamic acid;Existence of trombotic state (Subaracnoid Hemmorage, gallBladder disease,Vein thrombosis, Emboli); Plavix ( Clopidogrel) consumption during 7 days before operation; Streptokinase consumption during 48 hours before operation; Patients with poor heart contraction power (EF<35%); Aspirin consumption with high dose during 48 hours before operation; Repeated heart surgery operation (Redo);Active liver disease; Patients with Hb<10 g/dl

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Amount of bleeding. Timepoint: During operation upto discharge. Method of measurement: Amount of bleeding from chest bottle per ml.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Sohrab Negargar

Tabriz University of Medical Sciences, Shahid Madani Hospital

mosharkesh@tbzmed.ac.irmosharkesh@gmail.comnaghipourb@tbzmed.ac.ir+98 41 3337 3919

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026