Patients candidate for total hip arthroplasty. Multiple injuries of hip and thigh
Conditions
Interventions
Intervention 1: . In intravenous tranexamic acid group (15mg/kg), transamine will administer by anesthesiologist and based on body weight in a time of 10 minute. Before skin incision and surgery, all
Treatment - Drugs
. In intravenous tranexamic acid group (15mg/kg), transamine will administer by anesthesiologist and based on body weight in a time of 10 minute. Before skin incision and surgery, all the patients rec
In tranexamic topical group,patients will recieve 3gr of tranexamic acid(6 vials) that diluted with normal saline intraoperatively by orthoped.After rimming of acetabulom 30 ml of above solution inse
Sponsors
Vice Chancellaor foe Research of Guilan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients who undergoing total hip arthroplasty surgery; 50-20 years old; ASA (American Society of Anesthesia) I-II; having HB= 10gr dl before surgery ; not receiving transfusion before surgery. The exclusion criteria: Emergency surgery; Hb<10mg/dl; The evidence for any condition of IHD or treatment; The evidence for hemorrhagic CVA ; SAH OR STROK; The evidence for TBI; Use of anticoagulant drug; any history of renal ; liver and anemia before operation; History of OCP consumption.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative and postoperative hemorrhage. Timepoint: after operation and 24 hours after that. Method of measurement: based on blod on suction and gauze counting and gilcher formula. | — |
Secondary
| Measure | Time frame |
|---|---|
| Packed cell. Timepoint: intraoperative and 24 hours after surgery. Method of measurement: number of packed cell. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Haghighi
Guilan University of Medical Sciences
Outcome results
None listed