preeclampsia. Gestational [pregnancy-induced] hypertension with significant proteinuria
Conditions
Interventions
Intervention 1: In the intervention group, 3 and 24 hours after newborn birth, 70 mg of silymarin is to be orally administered to mother. Intervention 2: In the control group, 3 and 24 hours after bir
Treatment - Drugs
In the intervention group, 3 and 24 hours after newborn birth, 70 mg of silymarin is to be orally administered to mother.
In the control group, 3 and 24 hours after birth, placebo is to be administered to the mother.
Sponsors
Shahrekord University Of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 30 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age between 20 and 30 years; BMI is to be 20 to 24;Gestational age is between 35 and 42 weeks at the time of termination of pregnancy; blood pressure before the termination of pregnancy is to be more than 90/140 mm Hg;The presence of Proteinuria in random urine samples before pregnancy termination; no history of hypertension, diabetes, kidney disease, Collagen vascular and other types of cardiovascular diseases; mother is supposed to be nulliparous; Singleton pregnancy not molar; termination of pregnancy is indicated By severe pre-eclampsia Exclusion criteria:presence of preeclampsia in mother
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Platlet count. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: count in mm3.;Blood pressure. Timepoint: q 3 hours in study. Method of measurement: mmHg.;Liver enzyme. Timepoint: before and 12,36 and 60 hours after trial. Method of measurement: labratoary kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of blood pressure crisis in study. Timepoint: q 3 hours. Method of measurement: bp >160/110 mmhg. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Sepide Miraj
Shahrekord University Of Medical Sciences
Outcome results
None listed