Female infertility. Female infertility associated with anovulation
Conditions
Interventions
Intervention 1: Intervention group 1: 100 mg of Clomiphene (Ovumid
Iran Hormone, Tehran, Iran) daily starting day 5 of the menses for 7 days plus 5 mg of Letrozole (Letrozole 2.5
SOHA Pharmaceutical Co, Tehran, Iran) daily starting day 5 of the menses for 5 days. Intervention 2: Intervention group 2: 100 mg of Clomiphene (Ovumid
Iran Hormone, Tehran, Iran) daily starting day 3 of the menses for 5 days plus HMG 150 I.U(Merional
IBSA Institute Biochimique SA, CH-6903 Lugano).
Treatment - Drugs
Intervention group 1: 100 mg of Clomiphene (Ovumid
SOHA Pharmaceutical Co, Tehran, Iran) daily starting day 5 of the menses for 5 days.
Intervention group 2: 100 mg of Clomiphene (Ovumid
IBSA Institute Biochimique SA, CH-6903 Lugano)
Sponsors
Vice Chancellor for research of Iran Univercity of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Women with history of infertility more over than one year and diagnosis of PCOS based on the revised 2003 consensus on diagnostic criteria; By clomiphene resistance that meant failure of ovulation after 100-150 mg CC for 5 days for 2-3 cycles and then resistant to letrozole 2.5 mg daily for 5 days for 2 cycles. Exclusion criteria: Women older than 40 years or younger than 20; fallopian tubes abnormality proved by hysterosalpingography; abnormal semen analysis for their partners according to the modified criteria of the World Health Organization; endocrine problem like hyper or hypo thyroidism, hyperprolactinemia; abnormal karyotype.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ovulation. Timepoint: Day 11 of the menstrual cycle. Method of measurement: Transvaginal ultrasound.;Pregnancy. Timepoint: After retard of mense. Method of measurement: Pregnancy test by missuring B-hCG.;The number of follicles. Timepoint: Day 11 of the menstrual cycle. Method of measurement: Transvaginal ultrasound.;Follicle size. Timepoint: Day 11 of the menstrual cycle. Method of measurement: Transvaginal ultrasound.;Endometrial thickness. Timepoint: Day 11 of the menstrual cycle. Method of measurement: Transvaginal ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Multiple pregnancies. Timepoint: 4-6 weeks after menstural delay. Method of measurement: pregnancy sonography.;Abortions under 20 weeks. Timepoint: after pegnancy. Method of measurement: pregnancy sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Sara Norouzi
Iran University of Medical Sciences
Outcome results
None listed