Assessing the application of beneficial bacteria in the prevention of ventilator-induced lung infections in patients in intensive care unit

The role of probiotics in the prevention of ventilator-associated pneumonia in patients admitted to intensive care units

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015090114170N1

Enrollment

Registered

2016-06-04

Start date

2015-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pneumonia. Pneumonia, unspecified

Interventions

Intervention 1: Intervention group in addition to routine health care intervention for prevention of VAP geting Lactobacillus rhamnosus GG at a rate of 3 × 109 colony-forming units (cfu), 3 times a da

Treatment - Drugs

Placebo

Intervention group in addition to routine health care intervention for prevention of VAP geting Lactobacillus rhamnosus GG at a rate of 3 × 109 colony-forming units (cfu), 3 times a day (in the form o

Control group in addition to routine health care intervention for prevention of VAP geting placebo (Lactose-free milk AL110) 3 times a day (in the form of gavage)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion critria: Patients with Endotracheal intubation and mechanical ventilation that according to the doctors idea the possibility of 95% for at least 72 hours will be intubation; Obtaining the informed consent of the guardian of the patients. Exclusion criteria: pregnant patients; immunosuppressive; prostatic heart valves; vascular grafts; heart trauma; history of rheumatic fever; endocarditis; congenital heart anomalies; gastro-intestinal damage; foregut surgery in this hospitalization; oropharyngeal mucosa damage; tracheostomy; patients unable to get probiotics in the first 24 hours after intubation; pneumonia at admission; history of antibiotics in the 4 weeks prior to admission to the ICU

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Developing of ventilator-associated pneumonia. Timepoint: The time of Developing of ventilator-associated pneumonia. Method of measurement: Diagnostic criteria of ventilator-associated pneumonia.	—

Secondary

Measure	Time frame
Average days of hospitalization in ICU. Timepoint: Until discharge from the ICU. Method of measurement: days.;Day of hospitalization. Timepoint: Until discharge from hospital. Method of measurement: days.;Duration of intubation and Developing VAP,. Timepoint: Until developing of pneumonia. Method of measurement: days.;Duration of mechanical ventilation. Timepoint: Until being intubated. Method of measurement: days.;The frequency of clostridim difficile associated diarrhea. Timepoint: At the time of diarrhea. Method of measurement: Stool toxin.;The frequency of diarrhea associated with ICU. Timepoint: At the time of diarrhea. Method of measurement: Stool exam and exclude other causes.;Ventilator associated pneumonia complications. Timepoint: Daily. Method of measurement: Chest X-ray, blood tests and others.;Clinical status of patients (complete remission, partial remission, untreated, death). Timepoint: Time of discharge from intensive care unit. Method of measurement: Clinical symptoms, chest x-ray, complications and other findings.	—

Measure

Time frame

Average days of hospitalization in ICU. Timepoint: Until discharge from the ICU. Method of measurement: days.;Day of hospitalization. Timepoint: Until discharge from hospital. Method of measurement: days.;Duration of intubation and Developing VAP,. Timepoint: Until developing of pneumonia. Method of measurement: days.;Duration of mechanical ventilation. Timepoint: Until being intubated. Method of measurement: days.;The frequency of clostridim difficile associated diarrhea. Timepoint: At the time of diarrhea. Method of measurement: Stool toxin.;The frequency of diarrhea associated with ICU. Timepoint: At the time of diarrhea. Method of measurement: Stool exam and exclude other causes.;Ventilator associated pneumonia complications. Timepoint: Daily. Method of measurement: Chest X-ray, blood tests and others.;Clinical status of patients (complete remission, partial remission, untreated, death). Timepoint: Time of discharge from intensive care unit. Method of measurement: Clinical symptoms, chest x-ray, complications and other findings.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNader Zarinfar

Infectious Department, Arak University of Medical Sciences, Arak, Iran

nzarinfar@yahoo.com+98 86 3325 8269

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026