radiotherapy induced diarrhea. Gastroenteritis and colitis due to radiation
Conditions
Interventions
Intervention 1: samples select from target population that assign at least 31patients to each of two treatment arms. Patients in interventional group receive traditional drug ,paste product,12.5 gr tw
Treatment - Drugs
samples select from target population that assign at least 31patients to each of two treatment arms. Patients in interventional group receive traditional drug ,paste product,12.5 gr two times daily fo
Patients in control group receive loperamide in a standard dosage(2 mg per every bowel habit with maximum daily dose12 mg) for one week.
Sponsors
Shiraz University Of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients with Grade 1 to Grade 3diarrhea, as described in Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0 and experienced during the 24-h period after a fraction of radiotherapy ;All patients had a histologically confirmed cancer ;age>18 years; absence of fever with white blood cell count of over 3,000/mm3. exclusion criteria: Patients with Grade 4 diarrhea; diarrhea or stool incontinence before the beginning of irradiation; renal failure; past history of gastrointestinal disorder known to cause diarrhea ;presence of an active intraluminal gastrointestinal tumor
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of loose bowel movement (stool). Timepoint: daily. Method of measurement: visual by paitent. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of diarrhea therapy. Timepoint: daily. Method of measurement: Recorded by patients in a special card.;Side effects. Timepoint: daily. Method of measurement: Recorded by patients in a special card. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactTavakoli Ali
Shiraz University Of Mdical Sciences
Outcome results
None listed