Study of oral zinc supplementation effect on type 2 diabetes

Study of oral zinc supplementation effect on the superoxide dismutase gene expression and enzyme activity, and oxidative stress index in overweight type 2 diabetic patients.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150831023838N1

Enrollment

Registered

2018-01-05

Start date

2018-01-06

Completion date

Unknown

Last updated

2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus. Type 2 diabetes mellitus

Interventions

Intervention 1: Intervention group: One day will take, 2 capsules of zinc gluconate 25 mg for 60 days. These capsules are made by ALHAVI Company in Iran. Intervention 2: Control group: One day will ta

Eligibility

Sex/Gender

All

Age

40 Years to 65 Years

Inclusion criteria

Inclusion criteria: Afflicted with type 2 diabetes mellitus BMI= 25-30 kg/m2 HbA1c =7

Exclusion criteria

Exclusion criteria: Smoking Taking diuretics Taking antibiotics Taking multivitamins containing zinc Gastrointestinal disorders Thyroid disorders Cancer history Renal disorders Liver disorders

Design outcomes

Primary

Measure	Time frame
Gene expresion of Superoxide dismutase. Timepoint: Before and 8 weeks after intervention. Method of measurement: Real time PCR.;Superoxide dismutase activity. Timepoint: Before and 8 weeks after intervention. Method of measurement: ELISA.;Serum levels of Zinc. Timepoint: Before and 8 weeks after intervention. Method of measurement: Atomic Absorption Spectroscopy.;Serum levels of Malondialdehyde. Timepoint: Before and 8 weeks after intervention. Method of measurement: ELISA.;Serum levels of Total Antioxidant Capacity. Timepoint: Before and 8 weeks after intervention. Method of measurement: ELISA.;Serum levels of Total Oxidant Capacity. Timepoint: Before and 8 weeks after intervention. Method of measurement: ELISA.;Serum levels of Nitrotyrosine. Timepoint: Before and 8 weeks after intervention. Method of measurement: ELISA.;Serum levels of Fasting Blood Suger. Timepoint: Before and 8 weeks after intervention. Method of measurement: spectroscopy.;Glycated hemoglobin. Timepoint: Before and 8 weeks after intervention. Method of measurement: High Efficiency Liquid Cgromotography (HPLC).;Serum levels of Cholestrol. Timepoint: Before and 8 weeks after intervention. Method of measurement: spectroscopy.;Serum levels of Triglycerid. Timepoint: Before and 8 weeks after intervention. Method of measurement: spectroscopy.;Serum levels of Insulin. Timepoint: Before and 8 weeks after intervention. Method of measurement: Electrochemiluminescence.;Height. Timepoint: Before the intervention. Method of measurement: Meter.;Weight. Timepoint: Before and 8 weeks after intervention. Method of measurement: Scales.	—

Measure

Time frame

Gene expresion of Superoxide dismutase. Timepoint: Before and 8 weeks after intervention. Method of measurement: Real time PCR.;Superoxide dismutase activity. Timepoint: Before and 8 weeks after intervention. Method of measurement: ELISA.;Serum levels of Zinc. Timepoint: Before and 8 weeks after intervention. Method of measurement: Atomic Absorption Spectroscopy.;Serum levels of Malondialdehyde. Timepoint: Before and 8 weeks after intervention. Method of measurement: ELISA.;Serum levels of Total Antioxidant Capacity. Timepoint: Before and 8 weeks after intervention. Method of measurement: ELISA.;Serum levels of Total Oxidant Capacity. Timepoint: Before and 8 weeks after intervention. Method of measurement: ELISA.;Serum levels of Nitrotyrosine. Timepoint: Before and 8 weeks after intervention. Method of measurement: ELISA.;Serum levels of Fasting Blood Suger. Timepoint: Before and 8 weeks after intervention. Method of measurement: spectroscopy.;Glycated hemoglobin. Timepoint: Before and 8 weeks after intervention. Method of measurement: High Efficiency Liquid Cgromotography (HPLC).;Serum levels of Cholestrol. Timepoint: Before and 8 weeks after intervention. Method of measurement: spectroscopy.;Serum levels of Triglycerid. Timepoint: Before and 8 weeks after intervention. Method of measurement: spectroscopy.;Serum levels of Insulin. Timepoint: Before and 8 weeks after intervention. Method of measurement: Electrochemiluminescence.;Height. Timepoint: Before the intervention. Method of measurement: Meter.;Weight. Timepoint: Before and 8 weeks after intervention. Method of measurement: Scales.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMojgan Asadi

Tehran University of Medical Sciences

asadim@tums.ac.ir+98 21 8863 1298

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026