Effect of N-acetyl cysteine on expression of Oxidation-Reduction genes during implantation window in women with Recurrent Implantation Failure

Effect of N-acetyl cysteine on expression of Oxidation-Reduction genes of (FKBP4 ,PRDX6,NRF1,NRF2,GPX3 and MTHFR) during implantation window in women with Recurrent Implantation Failure: A Randomized, Placebo-Controlled, patient and assessor blinded, Phase 2 Clinical Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150831023831N2

Enrollment

Registered

2018-04-14

Start date

2015-05-22

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female Infertility. Female infertility

Interventions

Intervention 1: Intervention group: administer 1200 mg of effervescent tablets of N-acetyl cysteine (NAC) daily about 6 weeks. Intervention 2: Control group: administer1200 mg of effervescent tablets

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age between 20 and 40 years At least twice implantation failure BMI in the normal range Patients prescribed drugs such as folic acid, iron, multivitamins, and supplements generally equal status

Exclusion criteria

Exclusion criteria: Irregular menstrual cycle Taking hormonal drugs except thyroid medication Patients with abnormal karyotype or chromosomal disorders Patients who have coagulation problems

Design outcomes

Primary

Measure	Time frame
Gene expression related to implantation. Timepoint: 9 weeks after intervention. Method of measurement: Real-time PCR.	—

Secondary

Measure	Time frame
Clinical pregnancy. Timepoint: 2 weeks after Embryo Transfer. Method of measurement: Measurement of quantitative serum ß-hCG.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Parvaneh Afsharian

Royan Institute

pafshar@royaninstitute.org+98 21 2356 2674

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026