Comparison of the Hemodynamic Changes of three regimens propofol,diazepam and etomidate during anesthesia induction in low EF CABG patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015082921669N2

Enrollment

150

Registered

2016-07-22

Start date

2014-02-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General anesthesia for patients with cardiac disease. Left ventricular failure

Interventions

Intervention 1: Eomidate 0.2 mg Hypnotic agent. Intervention 2: Propofol 1.5 mg/kg Hypnotic agent. Intervention 3: Diazepam 0.3 mg/kg Hypnotic agent. Intervention 4: Midazolam 0.03 mg/kg as premedicat

Treatment - Drugs

Eomidate 0.2 mg Hypnotic agent

Propofol 1.5 mg/kg Hypnotic agent

Diazepam 0.3 mg/kg Hypnotic agent

Midazolam 0.03 mg/kg as premedication 1 minute before induction of anesthesia

Fentanyl (2µg/kg) as premedication drug 1 minutes before induction of anesthesia

Succinylcholine 1.5 mg/kg as muscle relaxationone minute after hypnotic drug administration

Eligibility

Sex/Gender

All

Age

35 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1- elective surgery. 2- aged 35_80 years old. 3- Ejection fraction (EF<35%). 4- Elective CABG surgery with CPB. Exclusion criteria : 1-adrenal insufficiency 2- history of steroid use in the preceding six months 3-sepsis,endocarditis,chronic inflammatory diseases 4,5-combined cardiac valve surgery with CABG and Bentall surgery. 6-tracheal intubation time more than 30 seconds

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Systolic and diastolic Blood pressure. Timepoint: During intervention. Method of measurement: sphygmomanometer/IBP.;Heart Rate. Timepoint: During intervention. Method of measurement: monitoring.;Mean arterial pressure. Timepoint: During intervention. Method of measurement: IBP.;Ejection fraction. Timepoint: One day before intervention. Method of measurement: Echocardiography.	—

Secondary

Measure	Time frame
Laryngoscopy duration. Timepoint: One minute after intubation. Method of measurement: Coronometer.;Weight. Timepoint: One day before intervention. Method of measurement: Documemt.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNeda Heidari

Mazandaran University of Medical Sciences

nedaheidari70@gmail.com+98 11 3332 8943

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026