Effects of N-acetyl cysteine on the improvement of cardiopulmonary and renal functions

Effects of N-acetyl cysteine on the improvement of cardiopulmonary and renal functions after cardiopulmonary bypass in patients with coronary artery bypass graft

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150825023760N8

Enrollment

Registered

2019-03-12

Start date

2013-12-10

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac coronary arterial disease. I26-I28

Interventions

Intervention 1: Intervention group: After induction, a central venous line was inserted and first blood sample (pre-CPB time) was obtained. After this stage, the NAC group received 100 mg/kg NAC. Int

Eligibility

Sex/Gender

All

Age

25 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria were patients with age 25-75 years undergoing cardio pulmonary bypass (CPB) for coronary artery bypass graft(CABG).

Exclusion criteria

Exclusion criteria: Exclusion criteria were patients for emergency coronary artery bypass graft(CABG) Redo CABG The intubation time after surgery for more than >10 hours Severe hemorrhage during coronary artery bypass graft (CABG)

Design outcomes

Primary

Measure	Time frame
Interleukin-6. Timepoint: The time points of blood sampling were after induction, before the administration of N-acetylcysteine (NAC) (pre-CPB)(Time 1) as baseline, one hour after CPB (on-CPB)(Time 2) , and one hour after that the patients were off-CPB (post-CPB)(Time 3). Method of measurement: Interleukin-6 measurement kit was used to measure Interleukin-6.;Shunt. Timepoint: The time points of blood sampling were after induction, before the administration of N-acetylcysteine (NAC) (pre-CPB)(Time 1) as baseline, one hour after CPB (on-CPB)(Time 2) , and one hour after that the patients were off-CPB (post-CPB)(Time 3). Method of measurement: Using the formula used to measure it.;Compliance reactive protein (CRP). Timepoint: The time points of blood sampling were after induction, before the administration of N-acetylcysteine (NAC) (pre-CPB)(Time 1) as baseline, one hour after CPB (on-CPB)(Time 2) , and one hour after that the patients were off-CPB (post-CPB)(Time 3). Method of measurement: Compliance reactive protein (CRP) measurement kit was used to measure Compliance reactive protein (CRP).;CKMB. Timepoint: The time points of blood sampling were after induction, before the administration of N-acetylcysteine (NAC) (pre-CPB)(Time 1) as baseline, one hour after CPB (on-CPB)(Time 2) , and one hour after that the patients were off-CPB (post-CPB)(Time 3). Method of measurement: Creatine kinase-muscle/brain (CKMB) measurement kit was used to measure creatine kinase-muscle/brain (CKMB).;Troponine. Timepoint: The time points of blood sampling were after induction, before the administration of N-acetylcysteine (NAC) (pre-CPB)(Time 1) as baseline, one hour after CPB (on-CPB)(Time 2) , and one hour after that the patients were off-CPB (post-CPB)(Time 3). Method of measurement: Troponine measurement kit was used to measure Troponine.;Serum Lactate. Timepoint: The time points of blood sampling were after induction, before the administration of N-acetylcysteine (NAC)	—

Measure

Time frame

Interleukin-6. Timepoint: The time points of blood sampling were after induction, before the administration of N-acetylcysteine (NAC) (pre-CPB)(Time 1) as baseline, one hour after CPB (on-CPB)(Time 2) , and one hour after that the patients were off-CPB (post-CPB)(Time 3). Method of measurement: Interleukin-6 measurement kit was used to measure Interleukin-6.;Shunt. Timepoint: The time points of blood sampling were after induction, before the administration of N-acetylcysteine (NAC) (pre-CPB)(Time 1) as baseline, one hour after CPB (on-CPB)(Time 2) , and one hour after that the patients were off-CPB (post-CPB)(Time 3). Method of measurement: Using the formula used to measure it.;Compliance reactive protein (CRP). Timepoint: The time points of blood sampling were after induction, before the administration of N-acetylcysteine (NAC) (pre-CPB)(Time 1) as baseline, one hour after CPB (on-CPB)(Time 2) , and one hour after that the patients were off-CPB (post-CPB)(Time 3). Method of measurement: Compliance reactive protein (CRP) measurement kit was used to measure Compliance reactive protein (CRP).;CKMB. Timepoint: The time points of blood sampling were after induction, before the administration of N-acetylcysteine (NAC) (pre-CPB)(Time 1) as baseline, one hour after CPB (on-CPB)(Time 2) , and one hour after that the patients were off-CPB (post-CPB)(Time 3). Method of measurement: Creatine kinase-muscle/brain (CKMB) measurement kit was used to measure creatine kinase-muscle/brain (CKMB).;Troponine. Timepoint: The time points of blood sampling were after induction, before the administration of N-acetylcysteine (NAC) (pre-CPB)(Time 1) as baseline, one hour after CPB (on-CPB)(Time 2) , and one hour after that the patients were off-CPB (post-CPB)(Time 3). Method of measurement: Troponine measurement kit was used to measure Troponine.;Serum Lactate. Timepoint: The time points of blood sampling were after induction, before the administration of N-acetylcysteine (NAC)

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Jamshidi

Zanjan University of Medical Sciences

jamshidianes@zums.ac.ir+98 24 3313 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026