The effect of hydrocortisone, vitamin C, and thiamine for treatment of septic shock

The effect of hydrocortisone , vitamin C, and thiamine for treatment of patients with septic shock addmited to intensive care unit of Ayatollah Mousavi hospital in Zanjan , in 2017-18

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150825023760N7

Enrollment

Registered

2019-02-22

Start date

2018-05-29

Completion date

Unknown

Last updated

2019-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic shock. Severe sepsis with septic shock

Interventions

Intervention 1: Intervention group: This group has received the assessed combination therapy, including hydrocortisone (50mg/each 6h, intravenously), vitamin C (1.5g/6h in 100ml DW5%, intravenously)

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: All patients with septic shock and the same Acute Physiology, Age, chronic health evaluation II (APACHE II score) admitted to intensive care unit Intubated patients Age between 18 to 70 years Serum pro-calcitonin level = 2ng/ml.

Exclusion criteria

Exclusion criteria: Pregnant patients

Design outcomes

Primary

Measure	Time frame
The Sequential organ function assessment (SOFA) score:a factor for evaluation of organ function. Timepoint: One day Later-Three days Later. Method of measurement: SOFA table was used to measure the performance of the organs.;Serum lactate( a factor for evaluation of Oran perfusion). Timepoint: One day Later-Three days Later. Method of measurement: Lactate measurement kit was used to measure lactate.;WBC count(leukocyte Count as a factor for evaluation of sepsis progression). Timepoint: One day Later-Three days Later. Method of measurement: Cell counters were used to measure the number of white blood cells.;Need for vasopressors (definition of septic shock is sepsis which requires treatment with vasopressors). Timepoint: One day later-Three days later. Method of measurement: For measuring the vasopressors, the average pressure is used, the unit is micrograms per minute.;Serum procalcitonin (indicator of sepsis severity). Timepoint: One day later-Three days later. Method of measurement: The measure of procalcitonin was VIDAS B.R.A.M.S PCT assy.	—

Measure

Time frame

The Sequential organ function assessment (SOFA) score:a factor for evaluation of organ function. Timepoint: One day Later-Three days Later. Method of measurement: SOFA table was used to measure the performance of the organs.;Serum lactate( a factor for evaluation of Oran perfusion). Timepoint: One day Later-Three days Later. Method of measurement: Lactate measurement kit was used to measure lactate.;WBC count(leukocyte Count as a factor for evaluation of sepsis progression). Timepoint: One day Later-Three days Later. Method of measurement: Cell counters were used to measure the number of white blood cells.;Need for vasopressors (definition of septic shock is sepsis which requires treatment with vasopressors). Timepoint: One day later-Three days later. Method of measurement: For measuring the vasopressors, the average pressure is used, the unit is micrograms per minute.;Serum procalcitonin (indicator of sepsis severity). Timepoint: One day later-Three days later. Method of measurement: The measure of procalcitonin was VIDAS B.R.A.M.S PCT assy.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Jamshidi

Zanjan University of Medical Sciences

jamshidianes@zums.ac.ir+98 24 3313 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026