The effect of livergol tablet in treatment of vitiligo

The Efficacy of photo-therapy plus livergol tablet (Silymarin) in comparison with photo-therapy plus placebo in treatment of patients with vitiligo referred to Shahid Faghihi Dermatology Clinic

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150825023753N9

Enrollment

Registered

2018-08-30

Start date

2017-04-21

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitiligo. Vitiligo

Interventions

Intervention 1: Intervention group: The initial dose of phothotherapy used in every patient is 250 mJ/cm2 and the energy is increased by 25 mJ/cm2 after every dose. The dose of livergol (manufactured

Eligibility

Sex/Gender

All

Age

14 Years to 70 Years

Inclusion criteria

Inclusion criteria: The patients with vitiligo Involving more than 20% of the body surface Age above 14 years old

Exclusion criteria

Exclusion criteria: Patients with systemic diseases Patients who use other therapeutic methods except light therapy Patients with any liver disease Patients with any kidney disease Pregnant and lactating women History of allergy to phototherapy History of allergy to Silymarin

Design outcomes

Primary

Measure	Time frame
The amount of melanin pigment in the skin. Timepoint: Assessment the amount of melanin pigment at the start of the study and 3 month after beginning the treatment. Method of measurement: Vitiligo Area Scoring Index (VASI Score).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Farideh Jowkar

Shiraz University of Medical Sciences

jowkarf@yahoo.com+98 71 3212 5592

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026