Post laser hyperpigmentation. Postinflammatory hyperpigmentation
Conditions
Interventions
Intervention 1: Intervention group: Patients will receive a combination formula (1:1 mixture of XYLA-P? and Janoberim?, ) on one side of the face, and after 30 minutes, each participant will receive a
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ??-?? years of age Patients with solar lentigo and freckles which is symmetrical on both sides of the face During the study, fertile women must be using effective contraception
Exclusion criteria
Exclusion criteria: Clinical active dermatological disease in the face• Wounds, dermatitis, tattoos or scars in treatment area• Current treatment with monoamine oxidase inhibitors, tricyclic or tetracyclic antidepressants which interacts with the noradrenergic transmission Current treatment with other systemic adrenergic receptor agonists or antagonists UV-exposure (solarium or sunbathing) or other treatment within the last month that enhances skin pigmentation Use of other topical agents that may interact with treatment Local or systemic treatment with photosensitizing drugs Pregnancy and breastfeeding women Current participation in other clinical trials Allergies to ingredients in birimonidine•
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post laser erythema. Timepoint: At the beginning of the study, then 30 minutes, 60 minutes, one month, and two months after receiving the interventions. Method of measurement: Clinician's Erythema Assessment (CEA).;The extent of post-laser inflammation-induced hyperpigmentation. Timepoint: One month and two months after receiving the interventions. Method of measurement: Physician clinical assessment and Likert scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain severity. Timepoint: During the laser procedure, immediately after, ?? minutes, ?? minutes after the procedure. Method of measurement: Likert scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mitra Abdolvand
Shiraz University of Medical Sciences
Outcome results
None listed