Comparison of fractional co2 laser therapy alone and with its combination with topical timolol or topical insulin in the treatment of acne scar

Comparison of fractional co2 laser therapy alone and with its combination with topical timolol or topical insulin in the treatment of acne scar, A randomized controlled clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150825023753N23

Enrollment

Registered

2024-01-17

Start date

2023-12-31

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne scar. Scar conditions and fibrosis of skin

Interventions

Intervention 1: Intervention group: Group A will receive fractional CO? laser therapy with distilled water on one side and the combination of fractional CO? laser therapy and topical Timolol Maleate

Eligibility

Sex/Gender

All

Age

15 Years to No maximum

Inclusion criteria

Inclusion criteria: The patients with moderate to severe atrophic acne scarring and no inflammatory lesions Age above 15 years old

Exclusion criteria

Exclusion criteria: Pregnant and lactating patients Patients who have inflammatory lesions Patients who have active Koebner-inducing diseases such as psoriasis and Lichen planus Patients who have Asthma, atrioventricular blocks, sinus bradycardia, diabetes mellitus Prior use of beta blockers, The patients who have received Isotretinoin in the past three months.

Design outcomes

Primary

Measure	Time frame
Severity of acne scar. Timepoint: At the beginning of the study and after two months. Method of measurement: Scale for Acne Scar Severity (SCAR-S),.;Acne Scar Assessment Scale. Timepoint: At the beginning of the study and after two months. Method of measurement: Acne Scar Assessment Scale (ASAS).;Grading of scar. Timepoint: At the beginning of the study and after two months. Method of measurement: Goodman and Baron quantitative global scarring grading system (GBAQGS).	—

Measure

Time frame

Severity of acne scar. Timepoint: At the beginning of the study and after two months. Method of measurement: Scale for Acne Scar Severity (SCAR-S),.;Acne Scar Assessment Scale. Timepoint: At the beginning of the study and after two months. Method of measurement: Acne Scar Assessment Scale (ASAS).;Grading of scar. Timepoint: At the beginning of the study and after two months. Method of measurement: Goodman and Baron quantitative global scarring grading system (GBAQGS).

—

Secondary

Measure	Time frame
Dermatologic Life Quality Index. Timepoint: At the beginning of the study and after two months. Method of measurement: Dermatologic Life Quality Index (DLQI) questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Sara Sadat Alavizadeh

Shiraz University of Medical Sciences

alavizadeh.sarah@gmail.com009832125592

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026