oral ketamin in treatment of patients with persistant somatoform pain disorder and mild to moderate depression

efficacy of oral ketamin compared to Diclofenac in treatment of patients with persistant somatoform pain disorder and mild to moderate depression: A double – blind controlled trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201508201556N80

Enrollment

Registered

2015-08-23

Start date

2015-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Major Depressive Disorder. Condition 2: Persistent somatoform pain disorder. Major Depressive episode persistant somatoform pain disorder

Interventions

Intervention 1: Capsule Ketamin 50 mgTDS as intervention group for 6 weeks. Intervention 2: Capsule Diclofenac 50 mg TDS as control group for 6 weeks.

Treatment - Drugs

Capsule Ketamin 50 mgTDS as intervention group for 6 weeks

Capsule Diclofenac 50 mg TDS as control group for 6 weeks

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:Mild to moderate major depressive disorder based on ICD-10 ; age between 18 to 60 years old ; score lower than 18 in Hamilton Rating Scale for depression ; confirmation of persistent somatoform pain disorder. Exclusion criteria: psychosis; receiving psychotropic medications; receiving any antidepressants during past one month or ECT during past two months; cardiovascular disease; pregnancy and breast feeding; any kind of cancer

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Severity of depression. Timepoint: Baseline and weeks3 and 6 after beginig of treatment. Method of measurement: by Hamiltion Depression Rating Scale 17-Item.	—

Secondary

Measure	Time frame
Severity of pain. Timepoint: Baseline and weeks3 and 6 after beginig of treatment. Method of measurement: by Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactProf. Shahin Akhondzadeh

Tehran University of Medical Sciences

s.akhond@sina.tums.ac.ir+98 21 5541 2222

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026