Major Depressive Disorder. Major Depressive episode
Conditions
Interventions
Intervention 1: Capsule Celecoxib200 mg BID as intervention group for 6 weeks. Intervention 2: Cap. placebo as control group for 6 weeks.
Treatment - Drugs
Placebo
Capsule Celecoxib200 mg BID as intervention group for 6 weeks
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1-Confirmation of colon cancer;2-receiving chemotherapy 3- score lower than 20 in Hamilton Rating Scale for depression 4-Mild to moderate major depressive disorder based on DSM-5 Exclusin criteria: 1-psychosis or other psychiatric disorder 2-Receiving psychotropic medications,3- receiving any antidepressants during past one month or ECT during past two months 4-history of cardiovascular disease , 5-pregnancy or breast feeding, 6-thyroid diseases
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depression. Timepoint: Baseline and weeks 2-4-6 after beginig of treatment. Method of measurement: by Hamiltion Depression Rating Scale 17-Item. | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of pain. Timepoint: Baseline and weeks 2-4-6 after beginig of treatment. Method of measurement: by Visual Analogue Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactProf. Shahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed