Nonalcoholic steatohepatitis. Fatty (change of) liver, not elsewhere classified
Conditions
Interventions
Intervention 1: Intervention group: Folic acid tablet, 5 mg, oral, once a day, for 6 months. Intervention 2: Control group: placebo tablet, oral, once a day, for 6months.
Sponsors
Ghoum University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients who are diagnosed to have non alcoholic fatty liver disease (grade 2 and 3) confirmed with ultrasonography and fibroscan results. Ages between 18-65 years Serum alanine transaminase enzyme level higher than 30 U/L
Exclusion criteria
Exclusion criteria: Having diseases such as liver disease and decompensated Cirrhosis Having diseases such as hereditary hemochromatosis and Wilson's disease Consumption of statins and hepatotoxic drugs such as calcium channel blocker, methotrexate, amiodarone and chloroquine Intake of folate, B12, vitamin E and omega-3 supplements during the last 6 months History of receiving total parenteral nutrition during last 6 months Pregnancy Lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver stiffness. Timepoint: At baseline and 24 weeks after the start of the intervention. Method of measurement: Fibroscan. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood levels of liver enzymes. Timepoint: At baseline and 24 weeks after the start of the intervention. Method of measurement: Blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAhmad Hormati
Ghoum University of Medical Sciences
Outcome results
None listed