The effects of vitamin D on endometriosis

Effects of vitamin D3 on Wnt/ß-catenin signaling pathway in the endometrium of women with endometriosis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015081823678N1

Enrollment

Registered

2015-09-29

Start date

2015-12-10

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometriosis. endometriosis

Interventions

Intervention 1: Control group 1: consist of the endometrium of women with deficiency of vitamin D (the serum concentration of 25 hydroxy vitamin D 30 or lower than 30 nano grams per milliliter). No in

Treatment - Drugs

Control group 1: consist of the endometrium of women with deficiency of vitamin D (the serum concentration of 25 hydroxy vitamin D 30 or lower than 30 nano grams per milliliter). No intervention will

Control group 2: consist of the endometrium of women with sufficiency of vitamin D (the serum concentration of 25 hydroxy vitamin D more than 30 nano grams per milliliter). No intervention will be don

endometriosis group 1: consist of the endometrium of women with endometriosis and deficiency of vitamin D (the serum concentration of 25 hydroxy vitamin D 30 or lower than 30 nano grams per milliliter

endometriosis group 2: consist of the endometrium of women with endometriosis and deficiency of vitamin D (the serum concentration of 25 hydroxy vitamin D 30 or lower than 30 nano grams per milliliter

Eligibility

Sex/Gender

Female

Age

22 Years to 37 Years

Inclusion criteria

Inclusion criteria: No usage of hormonal drugs, hormonal contraceptives, IUDs and supplements during the last 6 months; No history of pregnancy or lactation during the last 3 months; No contraindication of vitamin D; Age 22-37 years old; Body mass index between 18.5 to 30 kilograms per squer meter.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Experission of gene an protein of APC. Timepoint: before and three monthes after sampling. Method of measurement: western blot and RT-PCR.;Experission of gene an protein of ß-catenin. Timepoint: before and three monthes after sampling. Method of measurement: western blot and RT-PCR.;Experission of gene an protein of DKK1. Timepoint: before and three monthes after sampling. Method of measurement: western blot and RT-PCR.;Experission of gene an protein of DKK2. Timepoint: before and three monthes after sampling. Method of measurement: western blot and RT-PCR.;Experission of gene an protein of WNT7. Timepoint: before and three monthes after sampling. Method of measurement: western blot and RT-PCR.;Experission of gene an protein ofCD44. Timepoint: before and three monthes after sampling. Method of measurement: western blot and RT-PCR.;The activity of GSK-3b. Timepoint: before and three monthes after sampling. Method of measurement: western blot.;Serum levels of 25(OH)D. Timepoint: before and three monthes after sampling. Method of measurement: Radioimmunoassay.	—

Measure

Time frame

Experission of gene an protein of APC. Timepoint: before and three monthes after sampling. Method of measurement: western blot and RT-PCR.;Experission of gene an protein of ß-catenin. Timepoint: before and three monthes after sampling. Method of measurement: western blot and RT-PCR.;Experission of gene an protein of DKK1. Timepoint: before and three monthes after sampling. Method of measurement: western blot and RT-PCR.;Experission of gene an protein of DKK2. Timepoint: before and three monthes after sampling. Method of measurement: western blot and RT-PCR.;Experission of gene an protein of WNT7. Timepoint: before and three monthes after sampling. Method of measurement: western blot and RT-PCR.;Experission of gene an protein ofCD44. Timepoint: before and three monthes after sampling. Method of measurement: western blot and RT-PCR.;The activity of GSK-3b. Timepoint: before and three monthes after sampling. Method of measurement: western blot.;Serum levels of 25(OH)D. Timepoint: before and three monthes after sampling. Method of measurement: Radioimmunoassay.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzar Paghohan

Tehran university of medical science

a-paghohan@razi.tums.ac.ir+98 21 6641 9072

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 24, 2026