Condition 1: bipolar disorder. Condition 2: depressive disorder. Bipolar affective disorder depressive episode
Conditions
Interventions
Intervention 1: intervention group: liothyronine tab 1 microgram per kilogram once daily in the morning and oral from 1 day before first ECT session to 1 month after last ECT session. Intervention 2:
Treatment - Drugs
Placebo
intervention group: liothyronine tab 1 microgram per kilogram once daily in the morning and oral from 1 day before first ECT session to 1 month after last ECT session.
control group: placebo tab with the same shape and size of liothyrone tablet,once daily in the morning and oral, from 1 day before first ECT session to 1 month after last ECT session.
Sponsors
Kashan University of Medical Science Vise Chancellor for Research
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: men and women 18 to 45 years old with mood disorder diagnosis(major depressive disorder or bipolar disorder)based on DSM4TR criteria; candidate of ECT; without sensitivity to liothyronine; negative pregnancy test before treatment initiation; using safe contraception during the study. exclusion criteria: unstable cardiovascular disease; history of myocardial infarction in past 3 months; current unstable angina; untreated endocrine disorders; uncontrolled hypertention; structural brain anomaly; cerebral infarct or hemorrhage in past 1 month; unstable or bleeding vascular anneurism; severe respiratory disorders that are contraindications of general anesthesia; decompensating heart problems; heart vulvular disorders; brain space occupying lesions leading to increased intracranial pressure; pregnancy; addiction( except smoking) during the study; ECT treatment in past 6 months; allergic reaction to liothyronine; mental retardation; delirium, dementia or other amnestic disorders; occurrence of ECT-induced delirium during the study; lithium administration during the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Memory. Timepoint: before first ECT session, before 4th ECT session, 1 month after last ECT session. Method of measurement: wechsler memory scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Altered thyroid function. Timepoint: before 4th ECT session and 1 month after last ECT session. Method of measurement: thyroid function blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactPooya Hazegh
Kashan University of Medical Science Vice Chancellor for Research
Outcome results
None listed