Levofloxacin effect on eradication of Helicobacter Pylori infection

A clinical trial to comparing the efficacy of Levofloxacin versus Clarithromycin on eradication of Helicobacter Pylori infection

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015081818124N2

Enrollment

120

Registered

2015-12-23

Start date

2015-02-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter Pylori infection. Helicobacter pylori

Interventions

Intervention 1: Intervention group will take 20 mg of Omeprazole capsule once daily, 1000 mg Amoxicillin capsule two times a day and 500 mg tablet of Levofloxacin once daily. Then Omeprazole will be c

Treatment - Drugs

Intervention group will take 20 mg of Omeprazole capsule once daily, 1000 mg Amoxicillin capsule two times a day and 500 mg tablet of Levofloxacin once daily. Then Omeprazole will be continued for ano

Control group will take 20 mg Omeprazole Capsule once daily, 1000 mg capsule of Amoxicillin and Clarithromycin 500 mg capsule two times a day. Then Omeprazole will be continued for another 4 weeks.

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria to this study: all patients undergoing upper endoscopic procedure with positive rapid urease test (RUT). Exclusion criteria from this study: pregnancy; Previous consumption proton pump inhibitors (PPI) or Bismuth in the preceding one month; Gastrointestinal (GI) bleeding or any complication of peptic ulcer disease (PUD); consumption of alcohol or substance; advanced chronic disease: Diabetes mellitus, Hypertension, Cirrhosis, Cerebrovascular attack, Renal insufficiency, Coronary artery disease and gastric cancer; lack of willingness to continue the treatment; lack of willingness to complete the period of treatment; suffering from any disease needing to consume another antibiotic or non-steroidal anti-inflammatory drugs (NSAIDs).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Eradication of Helicobacter Pylori infection. Timepoint: Two months after beginning of treatment. Method of measurement: Primary evaluation of Helicobacter Pylori infection is based on rapid urease test and then eradication will be assessed by Helicobacter Pylori stool antigen.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Ali Akbar Haj Agha Mohammadi

Qazvin University of Medical Sciences

Ahmohammadi@qums.ac.ir+98 28 3379 0623

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026