The effect of N-Acetyl cysteine on sperm function, after Varicocelectomy

Evaluation of the effect of N-Acetyl cysteine on sperm parameters, sperm chromatin and oxidative s

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201508177223N5

Enrollment

Registered

2015-10-19

Start date

2012-05-14

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male factor infertility. Male infertility

Interventions

Intervention 1: Intervention group or NAC group: the individuals with varicocele received three tablets of NAC post varicocelectomy (200 mg daily) for three months. Intervention 2: Control group: The

Treatment - Drugs

Placebo

Intervention group or NAC group: the individuals with varicocele received three tablets of NAC post varicocelectomy (200 mg daily) for three months.

Control group: The individuals with varicocele received placebo after varicocelectomy.

Eligibility

Sex/Gender

Male

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Infertile men with primary infertility and left-sided varicocele (grade II and III) and without female factor infertility. Exclusion criteria: Men with grade I varicocele, Azoospermia, leukocytospermia, anatomical disorders, consumption of drug and occupational exposure

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Sperm motility. Timepoint: In day of surgery. Method of measurement: Optical microscope, based WHO criteria (2010).;Sperm concentration. Timepoint: In day of surgery. Method of measurement: Optical microscope, based WHO criteria (2010).;Sperm morphology. Timepoint: In day of surgery. Method of measurement: Optical microscope, based WHO criteria (2010).;DNA fragmentation. Timepoint: In day of surgery. Method of measurement: Fluorescent microscope.;Percentages of ROS positive sperm. Timepoint: In day of surgery. Method of measurement: flow cytometery.;Protamine deficiency. Timepoint: In day of surgery. Method of measurement: Fluorescent microscope.;Pregnancy outcome. Timepoint: 3 months post-surgery. Method of measurement: phone.	—

Measure

Time frame

Sperm motility. Timepoint: In day of surgery. Method of measurement: Optical microscope, based WHO criteria (2010).;Sperm concentration. Timepoint: In day of surgery. Method of measurement: Optical microscope, based WHO criteria (2010).;Sperm morphology. Timepoint: In day of surgery. Method of measurement: Optical microscope, based WHO criteria (2010).;DNA fragmentation. Timepoint: In day of surgery. Method of measurement: Fluorescent microscope.;Percentages of ROS positive sperm. Timepoint: In day of surgery. Method of measurement: flow cytometery.;Protamine deficiency. Timepoint: In day of surgery. Method of measurement: Fluorescent microscope.;Pregnancy outcome. Timepoint: 3 months post-surgery. Method of measurement: phone.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Hossein Nasr-Esfahani

Royan Institute (Royan Institute for Biotechnology)

mh_nasr@med.mui.ac.ir+98 31 9501 5688

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 1, 2026