Dextromethorphan effect on nausea and vomiting

Effect of oral dextromethorphan on postoperative nausea and vomiting after nose mucosal surgery in admitted patients in Valiasr hospital in Zanjan in 1394.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015081723661N1

Enrollment

Registered

2015-10-27

Start date

2015-07-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea and Vomiting. Nausea and vomiting

Interventions

Intervention 1: dextromethorphan syrp 90 mg/kg 3 hours before surgery in case group. Intervention 2: 90mg/kg oral sugar solution as placebo 3 hours before surgery in control group.

Prevention

dextromethorphan syrp 90 mg/kg 3 hours before surgery in case group.

90mg/kg oral sugar solution as placebo 3 hours before surgery in control group.

Eligibility

Sex/Gender

All

Age

15 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:Admitted patients undergoing elective nasal mucosal surgery;Any Riskfactors for Anesthesia (ASA I ,II ); Ages between 15-50. Exclusion criteria:Personal discontent; Medications that reduce or stimulate post operative nausea and vomiting; History of GI surgery; Pregnants; Fasting time less than 8 hours; long and difficult intubation; Drug allergy.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Nausea and vomiting. Timepoint: 12 & 24 hrs after surgery. Method of measurement: Rhode index.	—

Secondary

Measure	Time frame
Vertigo. Timepoint: 12 & 24 hrs after surgery. Method of measurement: questionnaire.;Respiratory distress. Timepoint: 12 & 24 hrs after surgery. Method of measurement: questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFateme Karimi

Zanjan University of Medical Sciences

dr.fateme.karimi@gmail.com+98 24 3347 0919

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026