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Comparing the effect of lidocaine and magnesium sulfate combination with amiodarone and magnesium sulfate combination in preventing ventricular fibrillation heart rhythms after aortic artery occlusion clamp removal during the coronary artery graft surgery

Comparing the effect of lidocaine- magnesium sulfate with amiodarone-magnesium sulfate in preventing ventricular fibrillation after aortic cross clamp removal in coronary artery graft surgery

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015081723660N1
Enrollment
70
Registered
2017-01-20
Start date
2015-03-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventricular fibrillation in coronary artery bypass graft operation. Ventricular fibrillation and flutter

Interventions

Intervention 1: All the patients received a standard monitoring, arterial and central venous catheter insertion. Premedication was applied by administering midazolam (0.05 mg/kg) with fentanyl (10 mic
Treatment - Drugs
All the patients received a standard monitoring, arterial and central venous catheter insertion. Premedication was applied by administering midazolam (0.05 mg/kg) with fentanyl (10 microgram/kg) and f

Sponsors

Hormozgan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: ASA class 3-4, atherosclerosis vessel coronary-history with no previous cardiopulmonary resuscitation, patients with no medication of digoxin-amiodarone-lidocaine-magnesium Exclusion criteria: Concurrent other cardiac surgery, emergency surgery, allergy to drugs

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Ventricular fibrillation. Timepoint: 15 minute before operation till 24 hours after operation in ICU. Method of measurement: Electrocardiography.

Secondary

MeasureTime frame
Central venous pressure. Timepoint: 15 minutes after anesthesia induction and 15 minutes after starting cardiopulmonary bypass. Method of measurement: Central venous pressure transducer monitor.;Mean arterial pressure. Timepoint: 15 minutes after anesthesia induction and 15 minutes after starting cardiopulmonary bypass. Method of measurement: Invasive arterial blood pressure monitor.;Heart rate. Timepoint: 15 minutes after anesthesia induction and 15 minutes after starting cardiopulmonary bypass. Method of measurement: electrocardiography monitor.;Arterial blood gases (pH, arterial partial pressure of oxygen, arterial partial pressure of carbon dioxide, bicarbonate concentration). Timepoint: At phases of (base line, heart arrest, patient warming, and pump separation). Method of measurement: Arterial catheter blood sampling.;Plasma (Na-K) electrolytes. Timepoint: At phases of (base line, heart arrest, patient warming, and pump separation). Method of measurement: Arterial catheter blood sampling.;Blood plasma glucose. Timepoint: At phases of (base line, heart arrest, patient warming, and pump separation). Method of measurement: Arterial catheter blood sampling.;Complete blood count of plasma. Timepoint: At phases of (base line, heart arrest, patient warming, and pump separation). Method of measurement: Arterial catheter blood sampling.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeid Kashani

Hormozgan University of Medical Sciences

sdkashani@gmail.com+98 76 3334 5009

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026