Comparison of two surgical methods for the treatment of ovarian cysts in endometriosis patients: Effect on ovarian reserve preservation.

A comparative study of the effect of cold knife cutting technique with bipolar coagulation in endometrioma cystectomy on ovarian reserve in patients with endometriosis: a clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150817023666N16

Enrollment

Registered

2025-08-11

Start date

2025-07-21

Completion date

Unknown

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with endometriosis.

Interventions

Intervention 1: Control group: Laparoscopic surgery for endometriosis and removal of bilateral ovarian endometriosis and endometrioma lesions using the conventional cystectomy method, which involves s

Eligibility

Sex/Gender

Female

Age

20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Women aged 20 to 35 with bilateral ovarian endometriomas measuring =3 cm, who are candidates for endometriosis surgery according to the guideline's recommendation At the time of enrollment, at least 3 months should have passed since the patient’s last hormonal therapy Having bilateral endometriomas

Exclusion criteria

Exclusion criteria: Previous history of laparotomy Uncontrolled diabetes History of allergies History of autoimmune diseases and other chronic diseases History of bleeding diseases or pelvic infections Malignancy or suspicion of malignancy on ultrasound Any endocrine disease that affects ovarian function, e.g. thyroid dysfunction, hyperprolactinemia

Design outcomes

Primary

Measure	Time frame
Ovarian reserve level. Timepoint: Changes in anti-Mullerian hormone levels in patients before, 3 months, and 9 months after surgery. Method of measurement: Measurement of serum anti-mullerian hormone (ELISA, Pars Azmoun kit).	—

Secondary

Measure	Time frame
Number of ovarian antral follicles. Timepoint: Before surgery and 3 and 9 months after surgery. Method of measurement: Ultrasound.;Follicle-stimulating hormone (FSH). Timepoint: Before surgery and 3 and 9 months after surgery. Method of measurement: Blood serum measurement (ELISA, Pars Azmoun kit).;Cancer antigen 125 (CA125). Timepoint: Before surgery and 3 and 9 months after surgery. Method of measurement: Blood serum measurement (ELISA, Pars Azmoun kit).;Pain during menstruation (dysmenorrhea). Timepoint: Before surgery and 3 and 9 months after surgery. Method of measurement: Visual Analogue Scale (VAS).;Pain during intercourse (dyspareunia). Timepoint: Before surgery and 3 and 9 months after surgery. Method of measurement: Visual Analogue Scale (VAS).	—

Measure

Time frame

Number of ovarian antral follicles. Timepoint: Before surgery and 3 and 9 months after surgery. Method of measurement: Ultrasound.;Follicle-stimulating hormone (FSH). Timepoint: Before surgery and 3 and 9 months after surgery. Method of measurement: Blood serum measurement (ELISA, Pars Azmoun kit).;Cancer antigen 125 (CA125). Timepoint: Before surgery and 3 and 9 months after surgery. Method of measurement: Blood serum measurement (ELISA, Pars Azmoun kit).;Pain during menstruation (dysmenorrhea). Timepoint: Before surgery and 3 and 9 months after surgery. Method of measurement: Visual Analogue Scale (VAS).;Pain during intercourse (dyspareunia). Timepoint: Before surgery and 3 and 9 months after surgery. Method of measurement: Visual Analogue Scale (VAS).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Abolfazl Mehdizadeh Kashi

Iran University of Medical Sciences

mehdizadeh.a@iums.ac.ir+98 21 6435 1000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026