Investigation of the effect of concentrated beetroot juice consumption in patients with type 2 diabetes

Effect of concentrated beetroot juice consumption on anthropometric measures, glycemic control, lipid profile, blood pressure, plasma systematic and vascular inflammation and oxidative stress, and NF-kB in peripheral blood mononuclear cells in patients with type 2 diabetes: Randomized clinical trial study

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150815023617N5

Enrollment

Registered

2020-12-06

Start date

2020-10-10

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes. Diabetes mellitus due to underlying condition

Interventions

Intervention 1: Intervention group: A12-week period of daily supplementation with 25 ml concentrated beetroot juice . Conc

Eligibility

Sex/Gender

All

Age

35 Years to 70 Years

Inclusion criteria

Inclusion criteria: ???Tendency to cooperate Patients with type 2 diabetes for 1-10 years Age between 35 to70 years old BMI between 20-25 kg/m2 No pregnancy or breast-feeding Patients who are only being treated with oral hypoglycemic agents No alcohol and substance abuse history

Exclusion criteria

Exclusion criteria: Patients who are using insulin Having chronic kidney, liver, or inflammatory diseases Taking multivitamin and herbal supplements in the past 3 months Taking glucocorticoids and nonsteroidal anti-inflammatory drugs Taking of nitrate-containing drugs such as nitroglycerin, isosorbide, nitropress, etc. History of microvascular and macrovascular diseases (such as history of angioplasty, foot vascular surgery) Patients with uncontrolled diabetes (HbA1C more than or equal 8.5%)

Design outcomes

Primary

Measure	Time frame
Plasma level of fasting plasma glucose. Timepoint: At the beginning (before the start of the study) and at the end of the study (12 weeks after the start of beet juice consumption). Method of measurement: Measuring by the colorimetric method based on the enzymatic reactions of invertase and glucose oxidase-peroxidase (GOD-POD).;HbA1C. Timepoint: At the beginning (before the start of the study) and at the end of the study (12 weeks after the start of beet juice consumption). Method of measurement: Chromatography.;HOMA-ß: The homeostasis model assessment of pancreatic ß-cell function. Timepoint: At the beginning (before the start of the study) and at the end of the study. Method of measurement: Calculating by formula: HOMA-B=20× Insulin (µU/m/glucose(mg/dl) -3.5.;HOMA-IR: Homeostatic model assessment of insulin resistance. Timepoint: At the beginning (before the start of the study) and at the end of the study. Method of measurement: Calculating by formula: HOMA-IR=(glucose(mg/dl)× Insulin(µU/ml))/22.5.	—

Measure

Time frame

Plasma level of fasting plasma glucose. Timepoint: At the beginning (before the start of the study) and at the end of the study (12 weeks after the start of beet juice consumption). Method of measurement: Measuring by the colorimetric method based on the enzymatic reactions of invertase and glucose oxidase-peroxidase (GOD-POD).;HbA1C. Timepoint: At the beginning (before the start of the study) and at the end of the study (12 weeks after the start of beet juice consumption). Method of measurement: Chromatography.;HOMA-ß: The homeostasis model assessment of pancreatic ß-cell function. Timepoint: At the beginning (before the start of the study) and at the end of the study. Method of measurement: Calculating by formula: HOMA-B=20× Insulin (µU/m/glucose(mg/dl) -3.5.;HOMA-IR: Homeostatic model assessment of insulin resistance. Timepoint: At the beginning (before the start of the study) and at the end of the study. Method of measurement: Calculating by formula: HOMA-IR=(glucose(mg/dl)× Insulin(µU/ml))/22.5.

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Secondary

Measure	Time frame
Body mass index. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet). Method of measurement: Weight in kilogram / the square of the height in centimeters.;Anthropometric measures: Weight. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet juice). Method of measurement: Using a digital scale.;Systolic and diastolic blood pressure. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet. Method of measurement: Standardized mercury sphygmomanometer.;HDL. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet). Method of measurement: Photometric enzymatic method.;Total -cholesterol. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet). Method of measurement: Photometric enzymatic method.;LDL-cholesterol. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet). Method of measurement: Using the Friedwald formula: LDL=TC -HDL - (TAG/5).;Intercellular Adhesion Molecule 1( ICAM-1). Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet). Method of measurement: ELISA.;Interleukin 6. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet). Method of measurement: ELISA.;High-sensitivity C-reactive protein (hs-CRP). Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet). Method of measurement: ELISA.;Malondialdehyde (MDA). Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consumin	—

Measure

Time frame

Body mass index. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet). Method of measurement: Weight in kilogram / the square of the height in centimeters.;Anthropometric measures: Weight. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet juice). Method of measurement: Using a digital scale.;Systolic and diastolic blood pressure. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet. Method of measurement: Standardized mercury sphygmomanometer.;HDL. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet). Method of measurement: Photometric enzymatic method.;Total -cholesterol. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet). Method of measurement: Photometric enzymatic method.;LDL-cholesterol. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet). Method of measurement: Using the Friedwald formula: LDL=TC -HDL - (TAG/5).;Intercellular Adhesion Molecule 1( ICAM-1). Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet). Method of measurement: ELISA.;Interleukin 6. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet). Method of measurement: ELISA.;High-sensitivity C-reactive protein (hs-CRP). Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consuming beet). Method of measurement: ELISA.;Malondialdehyde (MDA). Timepoint: At the beginning of the study (before the intervention) and at the end of the study (12 weeks after consumin

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactGolbon Sohrab

Shahid Beheshti University of Medical Sciences

golbonsohrab@sbmu.ac.ir+98 21 2207 7424

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 14, 2026