Primary dysmenorrhea. Primary dysmenorrhea
Conditions
Interventions
Intervention 1: Intervention Group: licorice syrup at a dose of 5 mL twice daily and placebo every 8 hours during the first five days of each cycle and for two consecutive cycles. Intervention 2: Cont
Treatment - Drugs
Intervention Group: licorice syrup at a dose of 5 mL twice daily and placebo every 8 hours during the first five days of each cycle and for two consecutive cycles
Control Group: Ibuprofen 400 mg every 8 hours and 5 ml of placebo syrup twice a day, during the first five days of each cycle and for two consecutive cycles
Sponsors
Vice Chancellor for research, Shahid Sadoughei University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 25 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Aged between 18-25 years; Moderate and severe dysmenorrhea (grade 2, 3) based on Verbal Multidimensional Scoring System; Regular menstrual cycles (every 21-35 days and bleeding 3 to 10 days for at least three recent cycles). Exclusion criteria: Pelvic pathology (including Endometriosis, Adenomyosis, Fibroids, Ovarian Cysts, Pelvic Inflammatory Disease, etc); Known diseases (including Chronic Hepatitis, Cholestatic Liver Disease, Cirrhosis, Severe Renal Insufficiency, Diabetes Mellitus, Arrhythmias, Hypertension, Hypertonia and Hypokalemia); Existence of stressors (such as loss of a close relative and Intense familial debate) during recent 6 months; History of allergy to licorice; Concurrent use of other products containing licorice; Taking another painkiller that is not defined in the study; Concomitant use of OCP; Drug intolerance; Lack of desire to continue the treatment for any reason; Another disease that will have required medical treatment during the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity. Timepoint: Before intervention- Every day during intervention. Method of measurement: Visual Analogue Scale(VAS).;Pain duration. Timepoint: Before intervention- Every day during intervention. Method of measurement: hour. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effect of licorice syrup. Timepoint: At the end of each cycle of intervention. Method of measurement: Questionnaire.;Adverse effect of Ibuprofen such as Nausea, dyspepsia, vomiting, ulcers and gastrointestinal bleeding. Timepoint: At the end of each cycle of intervention. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactzahra jafari
Faculty of Traditional Medicine, Shahid Sadoughei University of Medical Sciences, Ardakan, Yazd
Outcome results
None listed