comparison of accelerated and conventional collagen cross-linking in treatment of keratoconus patients

Comparison of accelerated and conventional corneal collagen cross-linking for progressive keratoconus in visual acuity, topographic indices, endothelial cell density in one year follow up

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015080723537N1

Enrollment

Registered

2015-09-06

Start date

2015-08-16

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratoconus. Keratoconus

Interventions

Intervention 1: conventional corneal cross-linking: soaking cornea with riboflavin0.1% in 30 minutes then irradiated cornea through ultraviolet A 3 mW/cm2 in 30 minute. Intervention 2: accelerated co

Treatment - Surgery

conventional corneal cross-linking: soaking cornea with riboflavin0.1% in 30 minutes then irradiated cornea through ultraviolet A 3 mW/cm2 in 30 minute.

accelerated corneal collagen cross-linking: soaking cornea with riboflavin 0.1% in 30 minutes then irradiated cornea through ultraviolet A 18 mW/cm2 in 5 minute

Eligibility

Sex/Gender

All

Age

12 Years to 35 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: keratoconus diagnosis based topography and orbscan. exclusion criteria: other ocular diseases; corneal ulcer involvement; surgical intervention duraton study; any corneal scar

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Uncorrected distance visual acuity. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: E chart.;Corrected distance visual acuity. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: E chart.;Endothelial cell density. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: specularmicroscopy.;Endothelial cell hexagunality. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: specularmicroscopy.;Coefficient of variation. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: specularmicroscopy.;Spherical equivalent. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: autorefractometer.;Thinnest point of cornea. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: orb scan.;K value in flat meridian. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: orb scan.;K value in steep meridian. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: orb scan.;Kmax. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: orb scan.;Keratometry astigmatism value(Kast). Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: orb scan.;Surface Asymmetry Index (SAI). Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: topography tomy.;Surcface Regularity Index ( SRI ). Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: topography tomy.;Keratoconus index (KCI). Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: topography tomy.;Keratoconus predication index (KPI). Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: topography tomy.;Keratoco	—

Measure

Time frame

Uncorrected distance visual acuity. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: E chart.;Corrected distance visual acuity. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: E chart.;Endothelial cell density. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: specularmicroscopy.;Endothelial cell hexagunality. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: specularmicroscopy.;Coefficient of variation. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: specularmicroscopy.;Spherical equivalent. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: autorefractometer.;Thinnest point of cornea. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: orb scan.;K value in flat meridian. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: orb scan.;K value in steep meridian. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: orb scan.;Kmax. Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: orb scan.;Keratometry astigmatism value(Kast). Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: orb scan.;Surface Asymmetry Index (SAI). Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: topography tomy.;Surcface Regularity Index ( SRI ). Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: topography tomy.;Keratoconus index (KCI). Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: topography tomy.;Keratoconus predication index (KPI). Timepoint: pre-intervention? 3? 6 and 12 month after intervention. Method of measurement: topography tomy.;Keratoco

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyyed Mohsen Moosazadeh M.D

Ahvaz, Jundishapur University of Medical Sciences

moosazadeh.m@ajums.ac.ir aboohashemmousa@gmail.com+98 61 3222 8076

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026