major thalassemia. Major thalassemia
Conditions
Interventions
Intervention 1: Intervention group : previous chelating agents + Amlodipine? 5mg, daily, for 12 months,Abidi company. Intervention 2: Control Group : previous chelating agents.
Treatment - Drugs
Intervention group : previous chelating agents + Amlodipine? 5mg, daily, for 12 months,Abidi company
Control Group : previous chelating agents
Sponsors
Vice Chancellor for research of Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Age
7 Years to 54 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients with major thalassemia ?? ?with ?regular blood transfusions; using iron chelating agents ?regularly; age above 7 years old.? Exclusion criteria: Patients who changed their chelating ?agents during the last 6 months; renal and hepatic ?failure; cardiac output less than 35%; systolic blood ?pressure less than 90 millimeter Hg, patients with HIV ?and hepatitis B and C.?
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ferritin Levels. Timepoint: Beginning and 1 and 6 and 12 months after treatment. Method of measurement: blood test.;Tissue iron level. Timepoint: Beginning, 6 months, 12months after treatment. Method of measurement: T2*MRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure. Timepoint: Monthly. Method of measurement: Barometer. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Aziz Eghbali
Arak University of Medical Siences
Outcome results
None listed