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Comparative study of the effectiveness of mouthwash containing either ozone water or chlorhexidine in the prevention of oral lesions and ventilation associated pneumonia in mechanically ventilated patients

Comparative study of the effectiveness of mouthwash containing either ozone water or chlorhexidine in the prevention of oral lesions and ventilation associated pneumonia in mechanically ventilated patients

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015080523520N1
Enrollment
80
Registered
2015-10-30
Start date
2013-10-17
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diseases of the respiratory system. Chapter X Diseases of the respiratory system (J00-J99)

Interventions

Intervention 1: In intervention group mouthwash with 0.05 ppm ozone water. Intervention 2: In the control group mouthwash containing 0.2% chlorhexidine.
Prevention
In intervention group mouthwash with 0.05 ppm ozone water
In the control group mouthwash containing 0.2% chlorhexidine

Sponsors

zanjan university of medical sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 76 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients who for 12 hours intubated and connect them mechanical ventilation and remained under mechanical ventilation during the study; patients aged 18-70 years; women who were not pregnant; no artificial teeth; had not severe anemia; had not alcohol poisoning; bleeding or sores in the mouth had not Exclusion criteria: Patients with mechanical ventilation ended in less than 48 hours; the patient died or for any reason or legal guardians of the patient and his doctor to participate in the study were withdrawn; despite the digestive tubes were vomiting during the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Oral lesions. Timepoint: after intervention, the second, third and fourth day of hospitalization. Method of measurement: Beck.

Secondary

MeasureTime frame
VAP. Timepoint: The first , third and fourth day of hospitalization. Method of measurement: CPIS.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasome masomi

Zanjan University of Medical Scienses

mmasoumi37@yahoo.com+98 24 3377 2513

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026