Bipolar disorder. Bipolar affective disorder, current episode manic without psychotic symptoms
Conditions
Interventions
Intervention 1: Intervention group: All patients treated with lithium , and risperidone and celecoxib. The dose of celecoxib is 100 mg twice a day. Intervention 2: Control group: All patients treated
Treatment - Drugs
Placebo
Intervention group: All patients treated with lithium , and risperidone and celecoxib. The dose of celecoxib is 100 mg twice a day.
Control group: All patients treated with lithium , risperidone and placebo. All patients received a starting dose of risperidone combined with lithium 1 mg in all patients, and within 10 days of the f
Sponsors
Vice chancellor for research, Tehran University of Medical Sciences, DR Masud Younesian
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Bipolar disorder (first episode); acute illness episode; manic phase; and Young Mania Rating Scale score 20 or more; age 12 to 18 years Exclusion criteria: Liver, kidney, heart and thyroid disorders at present; history of renal dysfunction or heart or a history of stomach ulcers; hypersensitivity to sulfonamides; co-morbidity risk of autism spectrum disorders; the risk of mental retardation; substance abuse over the past year; Mood Disorder caused by physical illness such as seizures; head trauma and other diseases
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bipolar disorder. Timepoint: Second week, Forth week, Week eight. Method of measurement: YMRS scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient function. Timepoint: Before treatment and at week eight. Method of measurement: CGAS Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyd Yaser Musavi
Tehran University of Medical Science
Outcome results
None listed