contrast induced nephropathy. Nephropathy induced by other drugs, medicaments and biological substances
Conditions
Interventions
Intervention 1: Intervention 1: In this group, the patients receive intravenous normal saline (0.9%) at a rate of 3 ml/kg one hour before angiography and 1 ml/kg per hour for 6 hours after angiography
Prevention
Intervention 1: In this group, the patients receive intravenous normal saline (0.9%) at a rate of 3 ml/kg one hour before angiography and 1 ml/kg per hour for 6 hours after angiography.
Intervention 2: In this group, the patients receive intravenous ringer lactate at rate of 3 ml/kg one hour before angiography and 1 ml/kg per hour for 6 hours after angiography.
Intervention 3: In this group, the patients receive intravenous sodium bicarbonate (850 ml DW 5% plus 150 mEq sodium bicarbonate) at a rate of 3 ml/kg one hour before angiography and 1 ml/kg per hour
Sponsors
vice chancellor for research, Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients over 18 y/o who have indications for coronary angiography and angioplasty are included. However, patients with hemodynamic instability, severe cardiac failure or pulmonary edema, under dialysis, under medications potentially affecting kidney function or with electrolyte and acid-base disturbances are not included. Exclusion criteria: patients with undesired complications such as arterial dissection during angiography or angioplasty are excluded from the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Creatinine. Timepoint: before and 48 hours after intervention. Method of measurement: Jaffe with adsorbent (picrate) method.;BUN. Timepoint: before and 48 hours after intervention. Method of measurement: urease/GLDH method.;Urine PH. Timepoint: before and 6 hours after intervention. Method of measurement: PH meter sticks.;Estimated GFR (eGFR). Timepoint: before and 48 hours after intervention. Method of measurement: MDRD equation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sodium and Potassium (Na and K). Timepoint: before and 48 hours after intervention. Method of measurement: flame photometry method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. M. Pakfetrat
Shiraz University of Medical Sciences
Outcome results
None listed