Effect of supplementation in treatment of women with polycystic ovary syndrome

Clinical trial of the effect of combined vitamin D and evening primrose oil supplementation on metabolic profiles and oxidative stress in women with polycystic ovary syndrome

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201508025623N48

Enrollment

Registered

2015-08-06

Start date

2015-08-03

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: Intervention group: Combined vitamin D and evening primrose oil pearl, 1000 IU vitamin D plus 1000 mg evening primrose oil, daily, for 12 weeks orally. Intervention 2: Control group: P

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Women aged 18-40 years diagnosed with PCOS

Exclusion criteria

Exclusion criteria: Elevated levels of prolactin Thyroid disorder Endocrine diseases including individuals with diabetes, impaired glucose tolerance Gastrointestinal diseases

Design outcomes

Primary

Measure	Time frame
Triglycerides. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Enzymatic kit.;HDL-cholesterol. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Enzymatic kit.;Total cholesterol. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Enzymatic kit.;LDL. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Enzymatic kit.;VLDL. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Enzymatic kit.	—

Measure

Time frame

Triglycerides. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Enzymatic kit.;HDL-cholesterol. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Enzymatic kit.;Total cholesterol. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Enzymatic kit.;LDL. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Enzymatic kit.;VLDL. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Enzymatic kit.

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Secondary

Measure	Time frame
Serum vitamin D. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Elisa kit.;Alopecia. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Clinical observation.;Total antioxidant. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Glutathione. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Modified Ferriman-Gallwey score. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Questionnaire.;Acne. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Clinical observation.	—

Measure

Time frame

Serum vitamin D. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Elisa kit.;Alopecia. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Clinical observation.;Total antioxidant. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Glutathione. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Modified Ferriman-Gallwey score. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Questionnaire.;Acne. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Clinical observation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactZatollah Asemi

Kashan University of Medical Sciences

asemi_r@yahoo.com+98 31 5546 3378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026