Evaluation the effect of gum containing petal extract of crocus sativus on gingival inflammation

Evaluation of the effect of gum containing petal extract of crocus sativus on gingival inflammation in fixed orthodontic patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150802023468N7

Enrollment

Registered

2021-05-19

Start date

2021-05-31

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gingivitis. Chronic gingivitis: NOS desquamative hyperplastic simple marginal ulcerative

Interventions

Intervention 1: Intervention group: The hydroalcoholic extract of Crocus sativus petal plant was extracted by soaking method and dried and concentrated by rotary distillation in vacuum, then gum conta

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Fixed orthodontic treatment plan

Exclusion criteria

Exclusion criteria: Systemic disease Tooth decay Use mouthwash or any other medication and gum during study

Design outcomes

Primary

Measure	Time frame
Gingival index. Timepoint: Baseline, one and two months after. Method of measurement: Inspection.;Probing depth. Timepoint: Baseline, one and two months after. Method of measurement: Periodontal probe.;Plaque index. Timepoint: Baseline, one and two months after. Method of measurement: Inspection.	—

Secondary

Measure	Time frame
Analgesic effect. Timepoint: One day, two days and three days after starting chewing gum. Method of measurement: Visual Analogue Scale Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNasim Khademi

Hamedan University of Medical Sciences

nasimkhademi1996@gmail.com+98 81 3838 1059

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026