Preeclampsia. Gestational [pregnancy-induced] hypertension with significant proteinuria
Conditions
Interventions
Intervention 1: Case group will administered 5 milligrams of folic acid daily from first trimester of pregnancy until termination. Intervention 2: case group will receive 1 milligram of folic acid dai
Treatment - Drugs
Case group will administered 5 milligrams of folic acid daily from first trimester of pregnancy until termination
case group will receive 1 milligram of folic acid daily from first trimester of pregnancy until termination
Sponsors
Isfahan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
17 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: all of women with living fetus in the uterine cavity in first trimester with willingness for participation in this study, were included and do not: Presence or history of a disorder in which administration of folic acid is contraindicated, renal diseases, using anti-epileptic drugs (since the metabolism of anti-epileptic drugs requires a great deal of folic acid), malignancy, alcohol abuse, multiple birth (presence of three living fetus or more) and known hypersensitivity to folic acid (rashes, dermatologic and gastroenterological discomforts). Exclusion criteria: Fetal death during the study, major abnormality of the fetus, women who were planning to move outside of the catchment area of the study within the pregnancy duration.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Preeclampsia. Timepoint: first visit and routin prenatal care. Method of measurement: measurement blod pressure (mmHg) and proteinuria(mg/dl). | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of preeclampsia. Timepoint: during pregnancy. Method of measurement: using diagnostic criteria.;Severity of preeclampsia. Timepoint: during pregnancy. Method of measurement: using diagnostic criteria.;Prevalence of preeclampsia. Timepoint: during pregnancy. Method of measurement: using diagnostic criteria. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Azar Danesh
Isfahan University of Medical Scineces
Outcome results
None listed